Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 590095..590670 | Replicon | chromosome |
| Accession | NZ_CP022133 | ||
| Organism | Idiomarina piscisalsi strain 10PY1A | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | CEW91_RS02760 | Protein ID | WP_088767570.1 |
| Coordinates | 590392..590670 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | graA | Uniprot ID | - |
| Locus tag | CEW91_RS02755 | Protein ID | WP_088767569.1 |
| Coordinates | 590095..590382 (-) | Length | 96 a.a. |
Genomic Context
Location: 588025..588345 (321 bp)
Type: Others
Protein ID: WP_088767567.1
Type: Others
Protein ID: WP_088767567.1
Location: 588342..589667 (1326 bp)
Type: Others
Protein ID: WP_088767568.1
Type: Others
Protein ID: WP_088767568.1
Location: 591821..592219 (399 bp)
Type: Others
Protein ID: WP_088767572.1
Type: Others
Protein ID: WP_088767572.1
Location: 592799..593779 (981 bp)
Type: Others
Protein ID: WP_088767574.1
Type: Others
Protein ID: WP_088767574.1
Location: 593772..594296 (525 bp)
Type: Others
Protein ID: WP_088767575.1
Type: Others
Protein ID: WP_088767575.1
Location: 594421..594618 (198 bp)
Type: Others
Protein ID: WP_088767576.1
Type: Others
Protein ID: WP_088767576.1
Location: 594633..594932 (300 bp)
Type: Others
Protein ID: WP_088767577.1
Type: Others
Protein ID: WP_088767577.1
Location: 585492..587636 (2145 bp)
Type: Others
Protein ID: WP_088767566.1
Type: Others
Protein ID: WP_088767566.1
Location: 589727..590077 (351 bp)
Type: Others
Protein ID: WP_198400882.1
Type: Others
Protein ID: WP_198400882.1
Location: 590095..590382 (288 bp)
Type: Antitoxin
Protein ID: WP_088767569.1
Type: Antitoxin
Protein ID: WP_088767569.1
Location: 590392..590670 (279 bp)
Type: Toxin
Protein ID: WP_088767570.1
Type: Toxin
Protein ID: WP_088767570.1
Location: 590752..591627 (876 bp)
Type: Others
Protein ID: WP_088767571.1
Type: Others
Protein ID: WP_088767571.1
Location: 592236..592724 (489 bp)
Type: Others
Protein ID: WP_088767573.1
Type: Others
Protein ID: WP_088767573.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CEW91_RS02735 | 585492..587636 | - | 2145 | WP_088767566.1 | TonB-dependent receptor | - |
| CEW91_RS02740 | 588025..588345 | + | 321 | WP_088767567.1 | helix-turn-helix domain-containing protein | - |
| CEW91_RS02745 | 588342..589667 | + | 1326 | WP_088767568.1 | type II toxin-antitoxin system HipA family toxin | - |
| CEW91_RS02750 | 589727..590077 | - | 351 | WP_198400882.1 | VOC family protein | - |
| CEW91_RS02755 | 590095..590382 | - | 288 | WP_088767569.1 | HigA family addiction module antidote protein | Antitoxin |
| CEW91_RS02760 | 590392..590670 | - | 279 | WP_088767570.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CEW91_RS02765 | 590752..591627 | - | 876 | WP_088767571.1 | DNA ligase | - |
| CEW91_RS02770 | 591821..592219 | + | 399 | WP_088767572.1 | DUF393 domain-containing protein | - |
| CEW91_RS02775 | 592236..592724 | - | 489 | WP_088767573.1 | MarR family transcriptional regulator | - |
| CEW91_RS02780 | 592799..593779 | + | 981 | WP_088767574.1 | catalase family peroxidase | - |
| CEW91_RS02785 | 593772..594296 | + | 525 | WP_088767575.1 | cytochrome b | - |
| CEW91_RS02790 | 594421..594618 | + | 198 | WP_088767576.1 | hypothetical protein | - |
| CEW91_RS02795 | 594633..594932 | + | 300 | WP_088767577.1 | Rho termination factor N-terminal domain-containing protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 580323..592219 | 11896 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10375.77 Da Isoelectric Point: 10.7124
>T78532 WP_088767570.1 NZ_CP022133:c590670-590392 [Idiomarina piscisalsi]
VIRNFKHKGLAKFFRFGSTAGIQASHAKRLRLILGRLNAASGTKDMDLPGLRLHELSGNRSGIWSVTVSGNWRVTFRFED
GDAEIVNYEDYH
VIRNFKHKGLAKFFRFGSTAGIQASHAKRLRLILGRLNAASGTKDMDLPGLRLHELSGNRSGIWSVTVSGNWRVTFRFED
GDAEIVNYEDYH
Download Length: 279 bp
>T78532 NZ_CP022133:c590670-590392 [Idiomarina piscisalsi]
GTGATCCGAAACTTCAAGCACAAAGGTTTGGCTAAGTTTTTCAGGTTCGGTAGCACCGCAGGGATTCAGGCCAGCCACGC
AAAGAGGCTTCGGCTTATTCTCGGTAGGTTGAATGCGGCATCTGGCACAAAAGATATGGATTTGCCAGGTCTTCGACTTC
ATGAGCTCTCCGGTAACCGCTCTGGAATTTGGTCAGTGACAGTCAGTGGAAACTGGCGCGTGACCTTCCGATTTGAGGAT
GGAGATGCAGAGATAGTAAATTATGAAGATTATCACTGA
GTGATCCGAAACTTCAAGCACAAAGGTTTGGCTAAGTTTTTCAGGTTCGGTAGCACCGCAGGGATTCAGGCCAGCCACGC
AAAGAGGCTTCGGCTTATTCTCGGTAGGTTGAATGCGGCATCTGGCACAAAAGATATGGATTTGCCAGGTCTTCGACTTC
ATGAGCTCTCCGGTAACCGCTCTGGAATTTGGTCAGTGACAGTCAGTGGAAACTGGCGCGTGACCTTCCGATTTGAGGAT
GGAGATGCAGAGATAGTAAATTATGAAGATTATCACTGA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10413.08 Da Isoelectric Point: 8.0936
>AT78532 WP_088767569.1 NZ_CP022133:c590382-590095 [Idiomarina piscisalsi]
MLMHNPPHPGEVLRELCLEPLGLSVTAAAEALGVSRKTLSAVLNGKAGISPEMAIRLSIAFNTSAESWLNQQSQYELWHA
EQHRKELKVKKLVAA
MLMHNPPHPGEVLRELCLEPLGLSVTAAAEALGVSRKTLSAVLNGKAGISPEMAIRLSIAFNTSAESWLNQQSQYELWHA
EQHRKELKVKKLVAA
Download Length: 288 bp
>AT78532 NZ_CP022133:c590382-590095 [Idiomarina piscisalsi]
ATGCTAATGCACAATCCCCCCCACCCTGGCGAAGTTTTACGAGAGCTTTGTCTCGAGCCTCTTGGCTTATCTGTAACCGC
TGCAGCGGAAGCTTTGGGCGTAAGCCGGAAAACGTTAAGTGCTGTTCTGAACGGCAAGGCTGGTATTAGCCCTGAAATGG
CTATCAGACTATCAATCGCATTTAATACTTCAGCGGAAAGCTGGCTAAACCAGCAGTCCCAGTATGAACTCTGGCATGCC
GAGCAACATCGTAAAGAACTCAAGGTTAAGAAGCTCGTTGCCGCATAA
ATGCTAATGCACAATCCCCCCCACCCTGGCGAAGTTTTACGAGAGCTTTGTCTCGAGCCTCTTGGCTTATCTGTAACCGC
TGCAGCGGAAGCTTTGGGCGTAAGCCGGAAAACGTTAAGTGCTGTTCTGAACGGCAAGGCTGGTATTAGCCCTGAAATGG
CTATCAGACTATCAATCGCATTTAATACTTCAGCGGAAAGCTGGCTAAACCAGCAGTCCCAGTATGAACTCTGGCATGCC
GAGCAACATCGTAAAGAACTCAAGGTTAAGAAGCTCGTTGCCGCATAA