Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 590095..590670 Replicon chromosome
Accession NZ_CP022133
Organism Idiomarina piscisalsi strain 10PY1A

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CEW91_RS02760 Protein ID WP_088767570.1
Coordinates 590392..590670 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag CEW91_RS02755 Protein ID WP_088767569.1
Coordinates 590095..590382 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEW91_RS02735 585492..587636 - 2145 WP_088767566.1 TonB-dependent receptor -
CEW91_RS02740 588025..588345 + 321 WP_088767567.1 helix-turn-helix domain-containing protein -
CEW91_RS02745 588342..589667 + 1326 WP_088767568.1 type II toxin-antitoxin system HipA family toxin -
CEW91_RS02750 589727..590077 - 351 WP_198400882.1 VOC family protein -
CEW91_RS02755 590095..590382 - 288 WP_088767569.1 HigA family addiction module antidote protein Antitoxin
CEW91_RS02760 590392..590670 - 279 WP_088767570.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEW91_RS02765 590752..591627 - 876 WP_088767571.1 DNA ligase -
CEW91_RS02770 591821..592219 + 399 WP_088767572.1 DUF393 domain-containing protein -
CEW91_RS02775 592236..592724 - 489 WP_088767573.1 MarR family transcriptional regulator -
CEW91_RS02780 592799..593779 + 981 WP_088767574.1 catalase family peroxidase -
CEW91_RS02785 593772..594296 + 525 WP_088767575.1 cytochrome b -
CEW91_RS02790 594421..594618 + 198 WP_088767576.1 hypothetical protein -
CEW91_RS02795 594633..594932 + 300 WP_088767577.1 Rho termination factor N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 580323..592219 11896


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10375.77 Da        Isoelectric Point: 10.7124

>T78532 WP_088767570.1 NZ_CP022133:c590670-590392 [Idiomarina piscisalsi]
VIRNFKHKGLAKFFRFGSTAGIQASHAKRLRLILGRLNAASGTKDMDLPGLRLHELSGNRSGIWSVTVSGNWRVTFRFED
GDAEIVNYEDYH

Download         Length: 279 bp

>T78532 NZ_CP022133:c590670-590392 [Idiomarina piscisalsi]
GTGATCCGAAACTTCAAGCACAAAGGTTTGGCTAAGTTTTTCAGGTTCGGTAGCACCGCAGGGATTCAGGCCAGCCACGC
AAAGAGGCTTCGGCTTATTCTCGGTAGGTTGAATGCGGCATCTGGCACAAAAGATATGGATTTGCCAGGTCTTCGACTTC
ATGAGCTCTCCGGTAACCGCTCTGGAATTTGGTCAGTGACAGTCAGTGGAAACTGGCGCGTGACCTTCCGATTTGAGGAT
GGAGATGCAGAGATAGTAAATTATGAAGATTATCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10413.08 Da        Isoelectric Point: 8.0936

>AT78532 WP_088767569.1 NZ_CP022133:c590382-590095 [Idiomarina piscisalsi]
MLMHNPPHPGEVLRELCLEPLGLSVTAAAEALGVSRKTLSAVLNGKAGISPEMAIRLSIAFNTSAESWLNQQSQYELWHA
EQHRKELKVKKLVAA

Download         Length: 288 bp

>AT78532 NZ_CP022133:c590382-590095 [Idiomarina piscisalsi]
ATGCTAATGCACAATCCCCCCCACCCTGGCGAAGTTTTACGAGAGCTTTGTCTCGAGCCTCTTGGCTTATCTGTAACCGC
TGCAGCGGAAGCTTTGGGCGTAAGCCGGAAAACGTTAAGTGCTGTTCTGAACGGCAAGGCTGGTATTAGCCCTGAAATGG
CTATCAGACTATCAATCGCATTTAATACTTCAGCGGAAAGCTGGCTAAACCAGCAGTCCCAGTATGAACTCTGGCATGCC
GAGCAACATCGTAAAGAACTCAAGGTTAAGAAGCTCGTTGCCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References