Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2166342..2166944 Replicon chromosome
Accession NZ_CP022132
Organism Francisella halioticida strain DSM 23729

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CDV26_RS11570 Protein ID WP_088773382.1
Coordinates 2166342..2166632 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag CDV26_RS11575 Protein ID WP_088773383.1
Coordinates 2166654..2166944 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDV26_RS11530 2161568..2161777 + 210 WP_088773375.1 hypothetical protein -
CDV26_RS11535 2161820..2162671 + 852 WP_088773376.1 recombination-associated protein RdgC -
CDV26_RS11540 2162664..2163098 + 435 WP_088773377.1 DUF3568 family protein -
CDV26_RS11545 2163199..2163474 + 276 WP_088773378.1 HU family DNA-binding protein -
CDV26_RS11550 2163477..2163992 + 516 WP_088773379.1 single-stranded DNA-binding protein -
CDV26_RS12335 2164009..2164215 + 207 WP_211276372.1 hypothetical protein -
CDV26_RS11555 2164190..2165428 + 1239 WP_088773380.1 DNA polymerase IV -
CDV26_RS11565 2165601..2166266 + 666 WP_088773381.1 DNA/RNA non-specific endonuclease -
CDV26_RS11570 2166342..2166632 + 291 WP_088773382.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDV26_RS11575 2166654..2166944 + 291 WP_088773383.1 HigA family addiction module antidote protein Antitoxin
CDV26_RS11580 2166989..2167363 + 375 WP_157671626.1 hypothetical protein -
CDV26_RS11585 2167407..2168105 + 699 WP_088773372.1 IS6 family transposase -
CDV26_RS11590 2168287..2168688 + 402 WP_088773385.1 hypothetical protein -
CDV26_RS11595 2168778..2170184 + 1407 WP_088773386.1 C69 family dipeptidase -
CDV26_RS11600 2170535..2171548 - 1014 WP_088773387.1 alanine racemase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2139427..2180494 41067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11248.84 Da        Isoelectric Point: 9.8351

>T78529 WP_088773382.1 NZ_CP022132:2166342-2166632 [Francisella halioticida]
MIINFASQSANDIYNGVSSKHARKIPNTIYKTAIRKLDMVNAAKVIEDLRIPPNNRLEQLKGNLKEYHSIRINDQYRVIF
KWKDNNAYDVDIVDYH

Download         Length: 291 bp

>T78529 NZ_CP022132:2166342-2166632 [Francisella halioticida]
ATGATAATAAATTTTGCAAGTCAATCAGCCAACGATATATATAATGGTGTCTCAAGTAAGCATGCTCGTAAAATACCAAA
TACAATATATAAAACAGCTATTAGAAAACTTGATATGGTTAATGCTGCCAAAGTTATAGAAGATTTAAGAATACCTCCTA
ATAATCGTTTAGAGCAATTAAAAGGCAATTTAAAAGAATATCACTCAATTAGAATAAACGACCAATATAGAGTGATATTT
AAATGGAAAGATAACAATGCTTATGATGTTGATATAGTTGATTATCATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10796.41 Da        Isoelectric Point: 6.9875

>AT78529 WP_088773383.1 NZ_CP022132:2166654-2166944 [Francisella halioticida]
MLIPSNRKPTHPGEILLHEFIEPLSITQTKLANHLGWTYARVNEIVNGKRGITADSALSLSETFGVTPDFWLNLQMLYDL
YSAKQTHKHVAPLEVA

Download         Length: 291 bp

>AT78529 NZ_CP022132:2166654-2166944 [Francisella halioticida]
ATGCTTATACCATCAAATAGAAAACCAACACATCCAGGTGAAATATTACTACATGAATTTATTGAACCTCTATCAATAAC
ACAAACAAAATTAGCAAATCATTTAGGTTGGACTTATGCAAGAGTTAATGAGATTGTAAATGGCAAAAGAGGAATAACAG
CCGACAGTGCATTATCATTAAGTGAAACTTTTGGAGTAACACCTGACTTTTGGCTAAATTTACAAATGCTATATGATTTA
TATAGTGCGAAACAGACACACAAACATGTGGCACCATTAGAGGTAGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References