Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2166342..2166944 Replicon chromosome
Accession NZ_CP022132
Organism Francisella halioticida strain DSM 23729

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CDV26_RS11570 Protein ID WP_088773382.1
Coordinates 2166342..2166632 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag CDV26_RS11575 Protein ID WP_088773383.1
Coordinates 2166654..2166944 (+) Length 97 a.a.

Genomic Context

CDV26_RS11530CDV26_RS11535CDV26_RS11540CDV26_RS11545CDV26_RS11550CDV26_RS12335CDV26_RS11555CDV26_RS11565CDV26_RS11570CDV26_RS11575CDV26_RS11580CDV26_RS11585CDV26_RS11590CDV26_RS11595CDV26_RS11600
Location: 2161568..2161777 (210 bp)
Type: Others
Protein ID: WP_088773375.1
Location: 2161820..2162671 (852 bp)
Type: Others
Protein ID: WP_088773376.1
Location: 2162664..2163098 (435 bp)
Type: Others
Protein ID: WP_088773377.1
Location: 2163199..2163474 (276 bp)
Type: Others
Protein ID: WP_088773378.1
Location: 2163477..2163992 (516 bp)
Type: Others
Protein ID: WP_088773379.1
Location: 2164009..2164215 (207 bp)
Type: Others
Protein ID: WP_211276372.1
Location: 2164190..2165428 (1239 bp)
Type: Others
Protein ID: WP_088773380.1
Location: 2165601..2166266 (666 bp)
Type: Others
Protein ID: WP_088773381.1
Location: 2166342..2166632 (291 bp)
Type: Toxin
Protein ID: WP_088773382.1
Location: 2166654..2166944 (291 bp)
Type: Antitoxin
Protein ID: WP_088773383.1
Location: 2166989..2167363 (375 bp)
Type: Others
Protein ID: WP_157671626.1
Location: 2167407..2168105 (699 bp)
Type: Others
Protein ID: WP_088773372.1
Location: 2168287..2168688 (402 bp)
Type: Others
Protein ID: WP_088773385.1
Location: 2168778..2170184 (1407 bp)
Type: Others
Protein ID: WP_088773386.1
Location: 2170535..2171548 (1014 bp)
Type: Others
Protein ID: WP_088773387.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CDV26_RS115302161568..2161777+210WP_088773375.1hypothetical protein-
CDV26_RS115352161820..2162671+852WP_088773376.1recombination-associated protein RdgC-
CDV26_RS115402162664..2163098+435WP_088773377.1DUF3568 family protein-
CDV26_RS115452163199..2163474+276WP_088773378.1HU family DNA-binding protein-
CDV26_RS115502163477..2163992+516WP_088773379.1single-stranded DNA-binding protein-
CDV26_RS123352164009..2164215+207WP_211276372.1hypothetical protein-
CDV26_RS115552164190..2165428+1239WP_088773380.1DNA polymerase IV-
CDV26_RS115652165601..2166266+666WP_088773381.1DNA/RNA non-specific endonuclease-
CDV26_RS115702166342..2166632+291WP_088773382.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CDV26_RS115752166654..2166944+291WP_088773383.1HigA family addiction module antidote proteinAntitoxin
CDV26_RS115802166989..2167363+375WP_157671626.1hypothetical protein-
CDV26_RS115852167407..2168105+699WP_088773372.1IS6 family transposase-
CDV26_RS115902168287..2168688+402WP_088773385.1hypothetical protein-
CDV26_RS115952168778..2170184+1407WP_088773386.1C69 family dipeptidase-
CDV26_RS116002170535..2171548-1014WP_088773387.1alanine racemase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2139427..218049441067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11248.84 Da        Isoelectric Point: 9.8351

>T78529 WP_088773382.1 NZ_CP022132:2166342-2166632 [Francisella halioticida]
MIINFASQSANDIYNGVSSKHARKIPNTIYKTAIRKLDMVNAAKVIEDLRIPPNNRLEQLKGNLKEYHSIRINDQYRVIF
KWKDNNAYDVDIVDYH

Download         Length: 291 bp

>T78529 NZ_CP022132:2166342-2166632 [Francisella halioticida]
ATGATAATAAATTTTGCAAGTCAATCAGCCAACGATATATATAATGGTGTCTCAAGTAAGCATGCTCGTAAAATACCAAA
TACAATATATAAAACAGCTATTAGAAAACTTGATATGGTTAATGCTGCCAAAGTTATAGAAGATTTAAGAATACCTCCTA
ATAATCGTTTAGAGCAATTAAAAGGCAATTTAAAAGAATATCACTCAATTAGAATAAACGACCAATATAGAGTGATATTT
AAATGGAAAGATAACAATGCTTATGATGTTGATATAGTTGATTATCATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10796.41 Da        Isoelectric Point: 6.9875

>AT78529 WP_088773383.1 NZ_CP022132:2166654-2166944 [Francisella halioticida]
MLIPSNRKPTHPGEILLHEFIEPLSITQTKLANHLGWTYARVNEIVNGKRGITADSALSLSETFGVTPDFWLNLQMLYDL
YSAKQTHKHVAPLEVA

Download         Length: 291 bp

>AT78529 NZ_CP022132:2166654-2166944 [Francisella halioticida]
ATGCTTATACCATCAAATAGAAAACCAACACATCCAGGTGAAATATTACTACATGAATTTATTGAACCTCTATCAATAAC
ACAAACAAAATTAGCAAATCATTTAGGTTGGACTTATGCAAGAGTTAATGAGATTGTAAATGGCAAAAGAGGAATAACAG
CCGACAGTGCATTATCATTAAGTGAAACTTTTGGAGTAACACCTGACTTTTGGCTAAATTTACAAATGCTATATGATTTA
TATAGTGCGAAACAGACACACAAACATGTGGCACCATTAGAGGTAGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References