Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 509369..510002 | Replicon | chromosome |
| Accession | NZ_CP022100 | ||
| Organism | Vibrio anguillarum strain S3 4/9 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | CEG15_RS15985 | Protein ID | WP_088729549.1 |
| Coordinates | 509369..509701 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A2K8XYD2 |
| Locus tag | CEG15_RS15990 | Protein ID | WP_071979346.1 |
| Coordinates | 509688..510002 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CEG15_RS15920 | 504378..504470 | + | 93 | WP_074544343.1 | DUF3265 domain-containing protein | - |
| CEG15_RS15925 | 504434..504775 | + | 342 | WP_157724219.1 | hypothetical protein | - |
| CEG15_RS15930 | 504768..505094 | + | 327 | WP_088729542.1 | threonyl-tRNA synthetase | - |
| CEG15_RS15935 | 505125..505217 | + | 93 | WP_198302706.1 | DUF3265 domain-containing protein | - |
| CEG15_RS15940 | 505244..505780 | + | 537 | WP_088729492.1 | nucleotidyltransferase family protein | - |
| CEG15_RS15945 | 505777..505887 | + | 111 | WP_088729824.1 | DUF3265 domain-containing protein | - |
| CEG15_RS15950 | 505921..506316 | + | 396 | WP_088729544.1 | DUF3465 domain-containing protein | - |
| CEG15_RS15955 | 506495..506899 | + | 405 | WP_088729545.1 | hypothetical protein | - |
| CEG15_RS15965 | 507727..508116 | + | 390 | Protein_457 | DUF1090 domain-containing protein | - |
| CEG15_RS15970 | 508120..508233 | + | 114 | WP_017045844.1 | DUF3265 domain-containing protein | - |
| CEG15_RS15975 | 508277..509146 | + | 870 | WP_088729547.1 | hypothetical protein | - |
| CEG15_RS15980 | 509139..509267 | + | 129 | WP_088729548.1 | DUF3265 domain-containing protein | - |
| CEG15_RS15985 | 509369..509701 | + | 333 | WP_088729549.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CEG15_RS15990 | 509688..510002 | + | 315 | WP_071979346.1 | DNA-binding transcriptional regulator | Antitoxin |
| CEG15_RS15995 | 510180..510416 | - | 237 | WP_013867767.1 | hypothetical protein | - |
| CEG15_RS16000 | 510730..510966 | - | 237 | WP_013867767.1 | hypothetical protein | - |
| CEG15_RS19810 | 511212..511373 | - | 162 | WP_194664201.1 | hypothetical protein | - |
| CEG15_RS16010 | 512191..512748 | + | 558 | WP_088729550.1 | nucleotidyltransferase family protein | - |
| CEG15_RS19710 | 512966..513490 | + | 525 | WP_157724221.1 | hypothetical protein | - |
| CEG15_RS16015 | 513371..514330 | - | 960 | WP_088729551.1 | IS30 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 503890..512748 | 8858 | |
| - | inside | Integron | - | - | 435402..647524 | 212122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 12890.76 Da Isoelectric Point: 10.0960
>T78433 WP_088729549.1 NZ_CP022100:509369-509701 [Vibrio anguillarum]
MKSVFVESTIFEKYRNDYLSDEEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMADLTADQKKQLKAFMEAWRNEQS
MKSVFVESTIFEKYRNDYLSDEEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMADLTADQKKQLKAFMEAWRNEQS
Download Length: 333 bp
>T78433 NZ_CP022100:509369-509701 [Vibrio anguillarum]
ATGAAAAGTGTATTTGTTGAATCAACCATATTTGAAAAGTACCGAAATGATTACCTCAGTGACGAGGAGTTTCGATTGTT
CCAAGCTGAACTTATGTCGAACCCGAAGCAAGGTGACGTAATTCAAGGTACTGGTGGTTTGCGGAAGATTCGAGTAGCAA
GTAAAGGTAAGGGAAAGCGTGGTGGTTCACGTGTTATCTATTACTTCCTCGATGAAAAGCGTCGCTTCTATTTACTGACT
ATTTACGGCAAAAATGAAATGGCAGACTTAACCGCAGATCAAAAGAAACAGTTAAAAGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTTGAATCAACCATATTTGAAAAGTACCGAAATGATTACCTCAGTGACGAGGAGTTTCGATTGTT
CCAAGCTGAACTTATGTCGAACCCGAAGCAAGGTGACGTAATTCAAGGTACTGGTGGTTTGCGGAAGATTCGAGTAGCAA
GTAAAGGTAAGGGAAAGCGTGGTGGTTCACGTGTTATCTATTACTTCCTCGATGAAAAGCGTCGCTTCTATTTACTGACT
ATTTACGGCAAAAATGAAATGGCAGACTTAACCGCAGATCAAAAGAAACAGTTAAAAGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11718.16 Da Isoelectric Point: 5.9765
>AT78433 WP_071979346.1 NZ_CP022100:509688-510002 [Vibrio anguillarum]
MSNRDLFAELNSALVEAKEHSEGKVTLKTHQVNDISELDISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELNSALVEAKEHSEGKVTLKTHQVNDISELDISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT78433 NZ_CP022100:509688-510002 [Vibrio anguillarum]
ATGAGCAATCGTGATCTATTTGCAGAGTTAAATTCTGCACTTGTTGAAGCTAAGGAGCATTCAGAGGGCAAAGTGACTCT
GAAAACTCATCAAGTTAATGACATCAGTGAGCTAGATATCTCACCTGATGAAATTGTTAGTATTCGTGAGCAGTTTAATA
TGTCTCGTGGTGTATTTGCTCGTTTACTGCATACATCATCACGTACATTGGAAAACTGGGAGCAGGGGCGGAGCGCACCA
AATGGGCAAGCTGTTACTCTTCTAAAACTGGTACAGCGCCACCCAGAAACTCTGTCGCACATCGCAGAGCTATAA
ATGAGCAATCGTGATCTATTTGCAGAGTTAAATTCTGCACTTGTTGAAGCTAAGGAGCATTCAGAGGGCAAAGTGACTCT
GAAAACTCATCAAGTTAATGACATCAGTGAGCTAGATATCTCACCTGATGAAATTGTTAGTATTCGTGAGCAGTTTAATA
TGTCTCGTGGTGTATTTGCTCGTTTACTGCATACATCATCACGTACATTGGAAAACTGGGAGCAGGGGCGGAGCGCACCA
AATGGGCAAGCTGTTACTCTTCTAAAACTGGTACAGCGCCACCCAGAAACTCTGTCGCACATCGCAGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|