Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 4336872..4337526 Replicon chromosome
Accession NZ_CP022097
Organism Pseudomonas protegens strain FDAARGOS_307

Toxin (Protein)


Gene name higB Uniprot ID Q4K9S3
Locus tag CEP86_RS20055 Protein ID WP_011062197.1
Coordinates 4337176..4337526 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q4K9S2
Locus tag CEP86_RS20050 Protein ID WP_011062198.1
Coordinates 4336872..4337189 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP86_RS20030 4332179..4332931 - 753 WP_011062202.1 UDP-2,3-diacylglucosamine diphosphatase -
CEP86_RS20035 4332928..4333431 - 504 WP_011062201.1 peptidyl-prolyl cis-trans isomerase -
CEP86_RS20040 4333702..4335402 + 1701 WP_011062200.1 glutamine--tRNA ligase/YqeY domain fusion protein -
CEP86_RS20045 4335421..4336803 + 1383 WP_011062199.1 cysteine--tRNA ligase -
CEP86_RS20050 4336872..4337189 - 318 WP_011062198.1 transcriptional regulator Antitoxin
CEP86_RS20055 4337176..4337526 - 351 WP_011062197.1 hypothetical protein Toxin
CEP86_RS20060 4337764..4339227 - 1464 WP_011062196.1 NADH-quinone oxidoreductase subunit NuoN -
CEP86_RS20065 4339235..4340767 - 1533 WP_011062195.1 NADH-quinone oxidoreductase subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4247038..4503513 256475


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(48-101)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13922.05 Da        Isoelectric Point: 9.6226

>T78430 WP_011062197.1 NZ_CP022097:c4337526-4337176 [Pseudomonas protegens]
MNALFIELPAFARYRKGFLDDELFCELQIELLRHPHAGVLIQGTGGLRKMRFVDERRNKGRRGGLRVIYYWWSGGAQFWL
FTLFDKEQMDDLLPQQRQQLKQLLEREIEARRHDQT

Download         Length: 351 bp

>T78430 NZ_CP022097:c4337526-4337176 [Pseudomonas protegens]
ATGAATGCTCTGTTTATTGAACTACCGGCATTTGCGCGATACCGAAAAGGCTTCCTTGACGACGAGTTGTTCTGCGAACT
GCAGATCGAGTTGCTGCGTCACCCGCACGCGGGTGTTCTGATTCAGGGCACTGGCGGCTTGCGCAAGATGCGTTTCGTCG
ATGAGCGACGCAACAAGGGCAGGCGTGGCGGGCTGAGGGTGATTTATTACTGGTGGTCCGGAGGAGCACAGTTCTGGCTC
TTCACCCTGTTCGACAAGGAGCAGATGGACGACCTGCTACCGCAGCAGCGACAACAGCTCAAACAACTGCTGGAACGTGA
AATCGAGGCCAGACGACATGACCAAACGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12064.95 Da        Isoelectric Point: 10.4439

>AT78430 WP_011062198.1 NZ_CP022097:c4337189-4336872 [Pseudomonas protegens]
MTKRDIFSELVEGIDALTQERQGKITLRSHKVKLEKLPPITAAEVMNIRQQLNLSRSVFAMYLRTNTRTLENWEQGRAIP
NAQATTLIRLVERYPDTVERLASLA

Download         Length: 318 bp

>AT78430 NZ_CP022097:c4337189-4336872 [Pseudomonas protegens]
ATGACCAAACGTGACATCTTTTCCGAACTGGTAGAAGGCATCGACGCCCTCACCCAGGAACGCCAGGGCAAGATCACCCT
GCGCAGCCATAAAGTGAAGCTCGAAAAGCTGCCGCCCATCACCGCCGCCGAGGTGATGAACATCCGCCAGCAACTCAACC
TCTCGCGCTCGGTATTCGCCATGTACCTGCGCACCAACACCCGCACCCTGGAGAACTGGGAACAGGGCCGCGCCATACCC
AACGCCCAGGCCACGACCTTGATACGCCTGGTGGAACGCTACCCCGATACAGTGGAGCGCCTCGCCTCGCTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4K9S3

Antitoxin

Source ID Structure
AlphaFold DB A0A2C9EPZ9

References