Detailed information of TA system TA078408

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1449..1967
• Replicon: plasmid unnamed1
• Accession: NZ_CP022091
• Organism: Staphylococcus saprophyticus strain FDAARGOS_355

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CEQ33_RS00020
• Protein ID: WP_011304050.1
• Coordinates: 1698..1967 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CEQ33_RS00015
• Protein ID: WP_011304051.1
• Coordinates: 1449..1697 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ33_RS00010	143..1141	+	999	WP_041785008.1	ThiF family adenylyltransferase	-
CEQ33_RS00015	1449..1697	+	249	WP_011304051.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CEQ33_RS00020	1698..1967	+	270	WP_011304050.1	Txe/YoeB family addiction module toxin	Toxin
CEQ33_RS00025	2190..2864	-	675	WP_011304049.1	IS6 family transposase	-
CEQ33_RS00030	3566..3844	-	279	WP_002508705.1	hypothetical protein	-
CEQ33_RS00035	3862..4539	-	678	WP_103314606.1	transposase	-
CEQ33_RS00040	4505..5770	-	1266	WP_011304047.1	replication initiator protein A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..38454	38454
	-	flank	IS/Tn	-	-	2190..2864	674

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10361.96 Da
• Isoelectric Point: 10.1510

>T78408 WP_011304050.1 NZ_CP022091:1698-1967 [Staphylococcus saprophyticus]
MAKLNITFSPQAFEDYEYFQLKDRPMVKRINKLLKSINRDGALGGIGKPEKLVGSLSGYYSRRINQEHRLVYTVNDTSIM
VASCRYHYR

Nucleotide

• Length: 270 bp

>T78408 NZ_CP022091:1698-1967 [Staphylococcus saprophyticus]
ATGGCTAAATTAAATATTACTTTTTCACCTCAAGCATTTGAAGATTATGAATACTTTCAGTTAAAAGATAGACCTATGGT
AAAGCGTATCAATAAATTGCTTAAAAGTATTAACAGAGATGGGGCTTTAGGAGGTATTGGGAAACCTGAAAAATTGGTTG
GTAGTCTTTCGGGATATTATAGTCGTCGGATTAATCAGGAACATAGATTAGTATATACGGTGAATGATACTTCAATCATG
GTTGCTTCATGTAGGTATCATTATAGATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9483.53 Da
• Isoelectric Point: 4.3525

>AT78408 WP_011304051.1 NZ_CP022091:1449-1697 [Staphylococcus saprophyticus]
VTVKNYTFVRDNFRDMINKVNDDSDTITITTKDRNAVLMSEDDYDAIMETLYLQQNPSNAKHLAESIENLERGNVKSKEI
EI

Nucleotide

• Length: 249 bp

>AT78408 NZ_CP022091:1449-1697 [Staphylococcus saprophyticus]
GTGACGGTTAAAAATTATACGTTCGTAAGAGATAATTTTAGAGATATGATTAATAAGGTAAATGATGATAGCGATACAAT
TACGATTACAACAAAAGACCGTAACGCTGTGTTGATGTCAGAAGATGATTACGACGCAATTATGGAAACATTATATCTTC
AACAAAATCCTTCCAACGCAAAACATTTAGCAGAATCAATTGAGAATTTAGAACGTGGTAATGTTAAAAGTAAGGAAATA
GAAATATAA