Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 8891360..8892054 Replicon chromosome
Accession NZ_CP022088
Organism Nocardia brasiliensis strain FDAARGOS_352

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag CEQ30_RS40280 Protein ID WP_043676543.1
Coordinates 8891360..8891737 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CEQ30_RS40285 Protein ID WP_042254154.1
Coordinates 8891734..8892054 (+) Length 107 a.a.

Genomic Context

CEQ30_RS40255CEQ30_RS40265CEQ30_RS40270CEQ30_RS40280CEQ30_RS40285CEQ30_RS40300CEQ30_RS40260CEQ30_RS40275CEQ30_RS40290CEQ30_RS40295CEQ30_RS40305
Location: 8886891..8887346 (456 bp)
Type: Others
Protein ID: WP_014987075.1
Location: 8888302..8889405 (1104 bp)
Type: Others
Protein ID: WP_042254150.1
Location: 8889440..8889871 (432 bp)
Type: Others
Protein ID: WP_042254151.1
Location: 8891360..8891737 (378 bp)
Type: Toxin
Protein ID: WP_043676543.1
Location: 8891734..8892054 (321 bp)
Type: Antitoxin
Protein ID: WP_042254154.1
Location: 8893945..8894364 (420 bp)
Type: Others
Protein ID: WP_042254159.1
Location: 8887363..8888088 (726 bp)
Type: Others
Protein ID: WP_042254149.1
Location: 8889819..8891018 (1200 bp)
Type: Others
Protein ID: WP_052382778.1
Location: 8892059..8892676 (618 bp)
Type: Others
Protein ID: WP_042254155.1
Location: 8892673..8893758 (1086 bp)
Type: Others
Protein ID: WP_042254157.1
Location: 8894517..8896316 (1800 bp)
Type: Others
Protein ID: WP_146154174.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CEQ30_RS402558886891..8887346+456WP_014987075.1DUF350 domain-containing protein-
CEQ30_RS402608887363..8888088-726WP_042254149.1TetR/AcrR family transcriptional regulator-
CEQ30_RS402658888302..8889405+1104WP_042254150.1FAD-dependent monooxygenase-
CEQ30_RS402708889440..8889871+432WP_042254151.1hypothetical protein-
CEQ30_RS402758889819..8891018-1200WP_052382778.1MFS transporter-
CEQ30_RS402808891360..8891737+378WP_043676543.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CEQ30_RS402858891734..8892054+321WP_042254154.1helix-turn-helix domain-containing proteinAntitoxin
CEQ30_RS402908892059..8892676-618WP_042254155.1MBL fold metallo-hydrolase-
CEQ30_RS402958892673..8893758-1086WP_042254157.1S-(hydroxymethyl)mycothiol dehydrogenase-
CEQ30_RS403008893945..8894364+420WP_042254159.1DUF1707 domain-containing protein-
CEQ30_RS403058894517..8896316-1800WP_146154174.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-89)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14546.57 Da        Isoelectric Point: 5.2733

>T78401 WP_043676543.1 NZ_CP022088:8891360-8891737 [Nocardia brasiliensis]
VDEWEIFITDEVEQFLDDLWKNDRQTHRLVNQAILLLERAGPAQGRPLVDCIAGSRIANMKELRPGSAGSSEIRILFVFD
PWRSAILLVAGDKAGAWQRWYRDAIPRAEKLYDAYLIERREELHR

Download         Length: 378 bp

>T78401 NZ_CP022088:8891360-8891737 [Nocardia brasiliensis]
GTGGACGAGTGGGAGATCTTCATAACCGATGAGGTAGAGCAGTTCCTCGACGATTTGTGGAAGAACGACCGCCAAACGCA
CCGATTGGTGAACCAGGCGATCTTGCTGCTGGAGCGAGCCGGGCCCGCGCAGGGGCGTCCGCTTGTCGACTGCATCGCAG
GGTCGCGGATCGCCAACATGAAGGAGCTGCGACCTGGTTCTGCAGGGAGTAGCGAGATCCGAATATTGTTCGTATTCGAT
CCGTGGCGGTCGGCCATCCTGCTGGTCGCCGGGGACAAGGCGGGCGCATGGCAGCGGTGGTATCGGGACGCGATACCGCG
CGCCGAAAAGCTTTACGACGCTTACTTGATCGAGCGACGCGAGGAGTTGCACCGATGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11911.38 Da        Isoelectric Point: 7.3221

>AT78401 WP_042254154.1 NZ_CP022088:8891734-8892054 [Nocardia brasiliensis]
MTTHRRWRDTGHLDRAVETASGPEEFEAGVEQLQDQARGWRLAELRKRRGLSQRQVAEHMGVSVARVSQIEKGEVATREV
LDRYVSALGGVLKLVADFGDEQLRVG

Download         Length: 321 bp

>AT78401 NZ_CP022088:8891734-8892054 [Nocardia brasiliensis]
ATGACCACTCATCGACGTTGGCGCGACACCGGCCATCTCGACCGTGCGGTCGAGACGGCCAGCGGGCCCGAGGAATTCGA
GGCCGGTGTCGAGCAGCTGCAGGACCAGGCGCGCGGCTGGCGACTGGCCGAACTGCGCAAGCGCCGAGGGCTCAGCCAAA
GACAAGTGGCGGAGCACATGGGCGTGTCCGTGGCACGCGTGTCGCAGATCGAAAAGGGTGAGGTCGCCACGCGGGAGGTG
TTGGACCGCTACGTCTCCGCGTTGGGCGGCGTGCTGAAGCTCGTCGCCGATTTCGGCGACGAGCAGTTGCGGGTGGGTTG
A

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References