Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2491828..2492443 Replicon chromosome
Accession NZ_CP022084
Organism Burkholderia cepacia strain FDAARGOS_345

Toxin (Protein)


Gene name higB Uniprot ID A0A806VP16
Locus tag CEQ23_RS36115 Protein ID WP_027789973.1
Coordinates 2491828..2492169 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A806UZQ0
Locus tag CEQ23_RS36120 Protein ID WP_027789974.1
Coordinates 2492156..2492443 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ23_RS36105 2488913..2490550 - 1638 WP_027789971.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -
CEQ23_RS36110 2490980..2491612 + 633 WP_027789972.1 LysE family translocator -
CEQ23_RS36115 2491828..2492169 + 342 WP_027789973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEQ23_RS36120 2492156..2492443 + 288 WP_027789974.1 helix-turn-helix transcriptional regulator Antitoxin
CEQ23_RS36125 2492523..2493212 - 690 WP_027789975.1 YebB family permuted papain-like enzyme -
CEQ23_RS36130 2493392..2493961 - 570 WP_027789976.1 hypothetical protein -
CEQ23_RS36135 2494182..2494640 - 459 WP_006749370.1 Lrp/AsnC family transcriptional regulator -
CEQ23_RS36140 2494767..2495501 + 735 WP_027789977.1 AzlC family ABC transporter permease -
CEQ23_RS36145 2495494..2495802 + 309 WP_027789978.1 AzlD family protein -
CEQ23_RS36150 2496121..2496900 + 780 WP_027789979.1 5'/3'-nucleotidase SurE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-90)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13112.25 Da        Isoelectric Point: 9.5171

>T78369 WP_027789973.1 NZ_CP022084:2491828-2492169 [Burkholderia cepacia]
MRTVADEIHFFSEQVEAGVFALPKTLIARFFALADRMEQYGPNPGEPHTRPMGDGLYEMRLKGLEDIARVFYCAVVNRRI
VMLHCYVKKTQKTPQKDLETARRRLKEIRDGNL

Download         Length: 342 bp

>T78369 NZ_CP022084:2491828-2492169 [Burkholderia cepacia]
ATGCGAACCGTCGCGGATGAAATCCATTTCTTCAGCGAGCAAGTCGAGGCTGGCGTATTTGCGTTGCCGAAAACGCTGAT
CGCCAGATTCTTCGCACTCGCTGACCGCATGGAGCAGTACGGCCCGAATCCGGGCGAACCTCACACCAGGCCGATGGGCG
ACGGGTTGTACGAAATGCGGTTGAAGGGCCTGGAAGATATCGCACGTGTGTTTTACTGCGCGGTCGTCAACCGGCGGATC
GTCATGCTTCACTGCTACGTGAAGAAGACGCAGAAAACGCCGCAGAAGGACCTGGAAACCGCGCGCCGCCGATTGAAGGA
GATTCGAGATGGCAACCTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10296.90 Da        Isoelectric Point: 9.6540

>AT78369 WP_027789974.1 NZ_CP022084:2492156-2492443 [Burkholderia cepacia]
MATYKALRERALADPTVCAEYDRLNREEFALLDAMLAARRAAGLSQADVAERMGTKAPAVTRLERALATGQHSPSIDTLR
KYAAACGKKLVISFA

Download         Length: 288 bp

>AT78369 NZ_CP022084:2492156-2492443 [Burkholderia cepacia]
ATGGCAACCTATAAGGCACTGCGCGAGCGCGCGTTGGCCGATCCGACGGTATGCGCCGAGTACGACCGGCTGAACCGCGA
GGAATTCGCGCTGCTCGACGCAATGCTGGCCGCCCGGCGAGCCGCCGGTCTTTCGCAAGCCGATGTGGCAGAGCGCATGG
GCACGAAGGCGCCTGCCGTCACGCGGCTCGAACGTGCGCTCGCGACAGGCCAGCACTCGCCGTCGATTGATACGCTGCGC
AAGTATGCGGCCGCATGCGGCAAGAAACTCGTGATCTCTTTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806VP16

Antitoxin

Source ID Structure
AlphaFold DB A0A806UZQ0

References