Detailed information of TA system TA078329

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 791051..791514
• Replicon: chromosome
• Accession: NZ_CP022059
• Organism: Enterococcus faecalis strain FDAARGOS_338

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: CEQ16_RS04185
• Protein ID: WP_002392696.1
• Coordinates: 791371..791514 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	791051..791195 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ16_RS04165	787698..788252	+	555	WP_002354869.1	septum formation protein Maf	-
CEQ16_RS04170	788385..788822	+	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
CEQ16_RS04175	788997..789968	+	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
CEQ16_RS04180	790022..790554	-	533	Protein_739	CPBP family intramembrane metalloprotease	-
-	791051..791195	-	145	-	-	Antitoxin
CEQ16_RS04185	791371..791514	+	144	WP_002392696.1	putative holin-like toxin	Toxin
CEQ16_RS04190	791884..792534	-	651	WP_002354875.1	beta-phosphoglucomutase	-
CEQ16_RS04195	792549..795293	-	2745	WP_002398920.1	glycoside hydrolase family 65 protein	-
CEQ16_RS04200	795555..796268	+	714	WP_002381063.1	trehalose operon repressor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T78329 WP_002392696.1 NZ_CP022059:791371-791514 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T78329 NZ_CP022059:791371-791514 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 145 bp

>AT78329 NZ_CP022059:c791195-791051 [Enterococcus faecalis]
TTGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGAT
TTTGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAACA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin