78314

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 686965..687405 Replicon chromosome
Accession NZ_CP022059
Organism Enterococcus faecalis strain FDAARGOS_338

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag CEQ16_RS03640 Protein ID WP_002381035.1
Coordinates 686965..687108 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 687207..687405 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ16_RS03635 682079..686770 + 4692 WP_010783624.1 WxL domain-containing protein -
CEQ16_RS03640 686965..687108 - 144 WP_002381035.1 putative holin-like toxin Toxin
- 687207..687405 + 199 - - Antitoxin
CEQ16_RS03645 687338..687478 - 141 WP_073340360.1 putative holin-like toxin -
CEQ16_RS03650 687597..687740 - 144 WP_002392818.1 putative holin-like toxin -
CEQ16_RS03655 688070..689686 - 1617 WP_105577398.1 phosphatase PAP2/LCP family protein -
CEQ16_RS03665 690379..691008 + 630 WP_002354763.1 lytic polysaccharide monooxygenase -
CEQ16_RS03670 691272..692264 - 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T78314 WP_002381035.1 NZ_CP022059:c687108-686965 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

>T78314 NZ_CP022059:c687108-686965 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 199 bp

>AT78314 NZ_CP022059:687207-687405 [Enterococcus faecalis]
TTTTTAGGTAATTGTGCTATAATGGTAATGAAAAGAGAGCTATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References