Detailed information of TA system TA078274

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokW/Ldr(toxin)
• Location: 2749388..2749609
• Replicon: chromosome
• Accession: NZ_CP022050
• Organism: Escherichia coli O157 strain FDAARGOS_293

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: CEP72_RS14305
• Protein ID: WP_001295224.1
• Coordinates: 2749502..2749609 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2749388..2749453 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP72_RS14275	2744828..2745730	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
CEP72_RS14280	2745741..2746724	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
CEP72_RS14285	2746721..2747725	+	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
CEP72_RS14290	2747755..2749026	-	1272	WP_001301684.1	amino acid permease	-
-	2749388..2749453	-	66	NuclAT_16	-	Antitoxin
-	2749388..2749453	-	66	NuclAT_16	-	Antitoxin
-	2749388..2749453	-	66	NuclAT_16	-	Antitoxin
-	2749388..2749453	-	66	NuclAT_16	-	Antitoxin
-	2749388..2749453	-	66	NuclAT_21	-	Antitoxin
-	2749388..2749453	-	66	NuclAT_21	-	Antitoxin
-	2749388..2749453	-	66	NuclAT_21	-	Antitoxin
-	2749388..2749453	-	66	NuclAT_21	-	Antitoxin
CEP72_RS14305	2749502..2749609	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
CEP72_RS14310	2749696..2751375	-	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
CEP72_RS14315	2751372..2751563	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
CEP72_RS14320	2751560..2753131	-	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
CEP72_RS14325	2753404..2753592	+	189	WP_001063316.1	YhjR family protein	-
CEP72_RS14330	2753604..2753801	+	198	WP_000279508.1	AAA family ATPase	-
CEP72_RS14335	2753820..2754356	+	537	WP_001270903.1	cellulose synthase operon protein YhjQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T78274 WP_001295224.1 NZ_CP022050:2749502-2749609 [Escherichia coli O157]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T78274 NZ_CP022050:2749502-2749609 [Escherichia coli O157]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT78274 NZ_CP022050:c2749453-2749388 [Escherichia coli O157]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin