Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 1731568..1731980 Replicon chromosome
Accession NZ_CP022050
Organism Escherichia coli O157 strain FDAARGOS_293

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag CEP72_RS09125 Protein ID WP_000132630.1
Coordinates 1731639..1731980 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 1731568..1731644 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP72_RS09115 1728195..1729664 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
CEP72_RS09120 1729664..1731418 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 1731568..1731644 - 77 NuclAT_14 - Antitoxin
- 1731568..1731644 - 77 NuclAT_14 - Antitoxin
- 1731568..1731644 - 77 NuclAT_14 - Antitoxin
- 1731568..1731644 - 77 NuclAT_14 - Antitoxin
- 1731568..1731644 - 77 NuclAT_15 - Antitoxin
- 1731568..1731644 - 77 NuclAT_15 - Antitoxin
- 1731568..1731644 - 77 NuclAT_15 - Antitoxin
- 1731568..1731644 - 77 NuclAT_15 - Antitoxin
CEP72_RS09125 1731639..1731980 + 342 WP_000132630.1 endoribonuclease SymE Toxin
CEP72_RS09130 1732027..1733190 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
CEP72_RS09135 1733238..1734119 - 882 WP_001304007.1 DUF262 domain-containing protein -
CEP72_RS09140 1734216..1734380 - 165 WP_000394274.1 DUF1127 domain-containing protein -
CEP72_RS09150 1734557..1735969 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
CEP72_RS31220 1736212..1736412 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 1723767..1744988 21221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T78270 WP_000132630.1 NZ_CP022050:1731639-1731980 [Escherichia coli O157]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T78270 NZ_CP022050:1731639-1731980 [Escherichia coli O157]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT78270 NZ_CP022050:c1731644-1731568 [Escherichia coli O157]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References