Detailed information of TA system TA078226

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2078802..2079335
• Replicon: chromosome
• Accession: NZ_CP022038
• Organism: Jonesia denitrificans strain FDAARGOS_301

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: C7QYS0
• Locus tag: CEP80_RS09945
• Protein ID: WP_015771937.1
• Coordinates: 2079081..2079335 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: C7QYS1
• Locus tag: CEP80_RS09940
• Protein ID: WP_015771938.1
• Coordinates: 2078802..2079080 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP80_RS09900	2074318..2074800	+	483	WP_015771946.1	pantetheine-phosphate adenylyltransferase	-
CEP80_RS09905	2074879..2075382	+	504	WP_105597337.1	hypothetical protein	-
CEP80_RS09910	2075589..2076080	+	492	WP_083775215.1	DUF177 domain-containing protein	-
CEP80_RS09915	2076083..2076277	+	195	WP_015771942.1	50S ribosomal protein L32	-
CEP80_RS09920	2076300..2077040	+	741	WP_049754459.1	ribonuclease III	-
CEP80_RS09925	2077047..2077976	+	930	WP_015771940.1	bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase	-
CEP80_RS09930	2077987..2078538	-	552	WP_015771939.1	GNAT family N-acetyltransferase	-
CEP80_RS09935	2078474..2078848	-	375	WP_083775133.1	hypothetical protein	-
CEP80_RS09940	2078802..2079080	+	279	WP_015771938.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CEP80_RS09945	2079081..2079335	+	255	WP_015771937.1	Txe/YoeB family addiction module toxin	Toxin
CEP80_RS09955	2079477..2080445	-	969	WP_015771936.1	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding subunit	-
CEP80_RS09960	2080591..2081214	+	624	WP_015771935.1	response regulator transcription factor	-
CEP80_RS09965	2081224..2082429	-	1206	WP_105597338.1	GAF domain-containing protein	-
CEP80_RS09970	2082495..2084276	-	1782	WP_015771933.1	thiol reductant ABC exporter subunit CydC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.50 Da
• Isoelectric Point: 6.7175

>T78226 WP_015771937.1 NZ_CP022038:2079081-2079335 [Jonesia denitrificans]
VRLVWDEAAWEDYKHWQTADRRVLKRINLLIDACLREPFEGIGKPEQLKYGVQGSWSRRINEEHRLVYLVDGDDLVILQA
RYHY

Nucleotide

• Length: 255 bp

>T78226 NZ_CP022038:2079081-2079335 [Jonesia denitrificans]
GTGCGGCTGGTTTGGGACGAGGCCGCCTGGGAGGACTACAAGCACTGGCAGACGGCCGACCGGAGGGTCCTCAAGCGGAT
CAACCTGCTCATTGACGCCTGCCTGCGCGAGCCGTTCGAGGGCATTGGCAAGCCTGAGCAGCTGAAGTACGGCGTGCAGG
GCTCGTGGTCCCGGCGGATCAATGAGGAGCACAGGCTCGTCTATCTCGTCGACGGCGACGATCTCGTGATCCTGCAGGCC
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10366.60 Da
• Isoelectric Point: 5.7185

>AT78226 WP_015771938.1 NZ_CP022038:2078802-2079080 [Jonesia denitrificans]
MSISASEARKTLFPLIERVNQDHEAIEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYDRARAGKVQAHELD
RSDEPADQPRGI

Nucleotide

• Length: 279 bp

>AT78226 NZ_CP022038:2078802-2079080 [Jonesia denitrificans]
ATGTCCATCAGCGCGAGCGAGGCCCGCAAGACGCTGTTTCCGCTCATCGAGCGCGTGAACCAGGATCACGAAGCTATCGA
GATCGTCTCCCGCAAGGGCAACGCGGTGCTCATGCCGGCCGACGAGTACGCCGCCTGGCAGGAGACCGCCTACCTGTTCC
GCTCGCCGGCGAACGCGCGCAGGCTGCTCGACGCCTACGACCGCGCCCGCGCCGGGAAGGTGCAGGCTCACGAACTCGAC
CGCTCCGACGAGCCCGCAGATCAGCCTCGGGGCATCTGA

Structures

Toxin

• AlphaFold DB: C7QYS0

Antitoxin

• AlphaFold DB: C7QYS1