Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 104684..105253 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP022016 | ||
| Organism | Salmonella enterica subsp. enterica serovar India str. SA20085604 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LFZ16_RS27630 | Protein ID | WP_154807612.1 |
| Coordinates | 104684..104965 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LFZ16_RS27635 | Protein ID | WP_223354026.1 |
| Coordinates | 104972..105253 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFZ16_RS27590 | 100005..100133 | - | 129 | WP_223353963.1 | hypothetical protein | - |
| LFZ16_RS27595 (LFZ16_28555) | 100390..100929 | - | 540 | WP_223353965.1 | lysozyme | - |
| LFZ16_RS27600 (LFZ16_28560) | 100907..101125 | - | 219 | WP_079908061.1 | phage holin | - |
| LFZ16_RS27615 (LFZ16_28575) | 102165..102605 | - | 441 | WP_223353966.1 | cell envelope integrity protein TolA | - |
| LFZ16_RS27630 (LFZ16_28590) | 104684..104965 | + | 282 | WP_154807612.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LFZ16_RS27635 (LFZ16_28595) | 104972..105253 | + | 282 | WP_223354026.1 | HigA family addiction module antitoxin | Antitoxin |
| LFZ16_RS27640 (LFZ16_28600) | 105343..106017 | - | 675 | WP_223353968.1 | bacteriophage antitermination protein Q | - |
| LFZ16_RS27645 (LFZ16_28605) | 106014..106619 | - | 606 | WP_223353970.1 | recombination protein NinG | - |
| LFZ16_RS27650 (LFZ16_28610) | 106612..106782 | - | 171 | WP_223354028.1 | NinE family protein | - |
| LFZ16_RS27655 (LFZ16_28615) | 106782..107237 | - | 456 | WP_223353972.1 | YbcN family protein | - |
| LFZ16_RS27660 | 107267..107344 | - | 78 | Protein_134 | DUF1367 family protein | - |
| LFZ16_RS27665 (LFZ16_28620) | 107580..107834 | + | 255 | WP_223353974.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LFZ16_RS27670 (LFZ16_28625) | 107834..108253 | + | 420 | WP_223353975.1 | type II toxin-antitoxin system VapC family toxin | - |
| LFZ16_RS27675 (LFZ16_28630) | 108385..108948 | - | 564 | WP_223353977.1 | hypothetical protein | - |
| LFZ16_RS27680 (LFZ16_28635) | 108948..109778 | - | 831 | WP_223353979.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | sopE2 / flhA / flhB / cheZ / cheY / cheB / cheR / cheW / cheA / motB / motA / flhC / flhD / fliA / fliS / fliG / fliI / fliM / fliN / fliP / fliQ / fliR / rcsA / sopA / sopA / ugd / gnd / ddhB / ddhA / galF / wcaJ / manB / wcaG / gmd / wza | 1..473456 | 473456 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10607.17 Da Isoelectric Point: 10.4689
>T78191 WP_154807612.1 NZ_CP022016:104684-104965 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MIKSFRHKGLERFFKTGSTSGIQAKHAVKLQIQLTALNVAKKPDDMAASGWELHPLRGNRLKGHWAVSVNGNWRLTFRFD
GEDAILVDYLDYH
MIKSFRHKGLERFFKTGSTSGIQAKHAVKLQIQLTALNVAKKPDDMAASGWELHPLRGNRLKGHWAVSVNGNWRLTFRFD
GEDAILVDYLDYH
Download Length: 282 bp
>T78191 NZ_CP022016:104684-104965 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGATCAAAAGCTTTCGCCACAAGGGACTTGAGAGATTTTTTAAAACCGGCTCAACTTCCGGCATACAGGCGAAGCACGC
AGTTAAACTTCAGATCCAGCTTACCGCCCTGAACGTTGCAAAAAAGCCTGATGATATGGCCGCTTCCGGCTGGGAGTTAC
ACCCACTCAGAGGAAATCGTCTGAAAGGACATTGGGCTGTATCCGTTAACGGTAACTGGCGACTGACGTTTCGCTTTGAT
GGCGAAGATGCGATCCTTGTTGACTATCTGGACTACCACTAA
ATGATCAAAAGCTTTCGCCACAAGGGACTTGAGAGATTTTTTAAAACCGGCTCAACTTCCGGCATACAGGCGAAGCACGC
AGTTAAACTTCAGATCCAGCTTACCGCCCTGAACGTTGCAAAAAAGCCTGATGATATGGCCGCTTCCGGCTGGGAGTTAC
ACCCACTCAGAGGAAATCGTCTGAAAGGACATTGGGCTGTATCCGTTAACGGTAACTGGCGACTGACGTTTCGCTTTGAT
GGCGAAGATGCGATCCTTGTTGACTATCTGGACTACCACTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10008.42 Da Isoelectric Point: 6.7217
>AT78191 WP_223354026.1 NZ_CP022016:104972-105253 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
IMRMHNPAHPGAVLREYLGDVSVTDAAKALNVTRAALSRILNGSAGISADMALRLEAALGTSAEMWTDMQSQYELWVASQ
GSRPEVKPIFSHA
IMRMHNPAHPGAVLREYLGDVSVTDAAKALNVTRAALSRILNGSAGISADMALRLEAALGTSAEMWTDMQSQYELWVASQ
GSRPEVKPIFSHA
Download Length: 282 bp
>AT78191 NZ_CP022016:104972-105253 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATTATGAGAATGCACAACCCCGCACATCCCGGCGCTGTTCTTCGTGAATACCTGGGGGATGTTTCTGTTACCGATGCAGC
AAAAGCGCTCAATGTTACGCGTGCCGCGCTTTCCCGTATTTTAAACGGAAGTGCAGGTATTTCTGCTGATATGGCACTGC
GTCTCGAAGCAGCTCTTGGAACCAGTGCTGAAATGTGGACTGACATGCAGTCTCAGTACGAGCTTTGGGTTGCATCGCAA
GGTAGCAGGCCGGAAGTTAAACCTATTTTTTCTCACGCCTGA
ATTATGAGAATGCACAACCCCGCACATCCCGGCGCTGTTCTTCGTGAATACCTGGGGGATGTTTCTGTTACCGATGCAGC
AAAAGCGCTCAATGTTACGCGTGCCGCGCTTTCCCGTATTTTAAACGGAAGTGCAGGTATTTCTGCTGATATGGCACTGC
GTCTCGAAGCAGCTCTTGGAACCAGTGCTGAAATGTGGACTGACATGCAGTCTCAGTACGAGCTTTGGGTTGCATCGCAA
GGTAGCAGGCCGGAAGTTAAACCTATTTTTTCTCACGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|