Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 81880..82610 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP022016 | ||
| Organism | Salmonella enterica subsp. enterica serovar India str. SA20085604 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LFZ16_RS27465 | Protein ID | WP_223353939.1 |
| Coordinates | 81880..82194 (+) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LFZ16_RS27470 | Protein ID | WP_223353941.1 |
| Coordinates | 82194..82610 (+) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFZ16_RS27440 (LFZ16_28410) | 77928..78683 | - | 756 | WP_223353933.1 | tail assembly protein | - |
| LFZ16_RS27445 (LFZ16_28415) | 78581..79318 | - | 738 | WP_223353935.1 | C40 family peptidase | - |
| LFZ16_RS27450 (LFZ16_28420) | 79329..80024 | - | 696 | WP_223353937.1 | phage minor tail protein L | - |
| LFZ16_RS27455 (LFZ16_28425) | 80189..81310 | - | 1122 | WP_080168950.1 | porin OmpC | - |
| LFZ16_RS27460 (LFZ16_28430) | 81463..81792 | - | 330 | WP_220540284.1 | phage tail protein | - |
| LFZ16_RS27465 (LFZ16_28435) | 81880..82194 | + | 315 | WP_223353939.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LFZ16_RS27470 (LFZ16_28440) | 82194..82610 | + | 417 | WP_223353941.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LFZ16_RS27475 (LFZ16_28445) | 82632..85745 | - | 3114 | WP_223353943.1 | phage tail tape measure protein | - |
| LFZ16_RS27480 (LFZ16_28450) | 85808..86116 | + | 309 | WP_023246428.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LFZ16_RS27485 (LFZ16_28455) | 86109..86399 | + | 291 | WP_023246427.1 | putative addiction module antidote protein | - |
| LFZ16_RS27490 (LFZ16_28460) | 86400..86618 | - | 219 | WP_023246426.1 | hypothetical protein | - |
| LFZ16_RS27495 (LFZ16_28465) | 86669..87070 | - | 402 | WP_023246425.1 | phage tail assembly chaperone | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | sopE2 / flhA / flhB / cheZ / cheY / cheB / cheR / cheW / cheA / motB / motA / flhC / flhD / fliA / fliS / fliG / fliI / fliM / fliN / fliP / fliQ / fliR / rcsA / sopA / sopA / ugd / gnd / ddhB / ddhA / galF / wcaJ / manB / wcaG / gmd / wza | 1..473456 | 473456 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12574.48 Da Isoelectric Point: 10.0564
>T78189 WP_223353939.1 NZ_CP022016:81880-82194 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MHLISMKAIHEAVNRYPQYKKELLQFGRNIEKGNCPTPEELKKIYPSLDNFKYLDKHYVIDIANNNIRIIAIVFFESQKF
YIRHVFNHSEYDRFTSQHRTKGKR
MHLISMKAIHEAVNRYPQYKKELLQFGRNIEKGNCPTPEELKKIYPSLDNFKYLDKHYVIDIANNNIRIIAIVFFESQKF
YIRHVFNHSEYDRFTSQHRTKGKR
Download Length: 315 bp
>T78189 NZ_CP022016:81880-82194 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGCACCTTATCTCAATGAAAGCGATCCATGAAGCAGTTAACAGATACCCTCAGTATAAAAAAGAGCTTCTACAGTTTGG
TCGGAACATAGAGAAAGGTAATTGCCCTACCCCCGAAGAGCTGAAAAAAATCTATCCATCTCTGGATAATTTTAAATATC
TGGATAAACATTATGTTATTGATATTGCAAACAATAATATAAGAATTATCGCAATTGTTTTTTTCGAGAGTCAGAAGTTT
TATATTCGCCATGTATTCAACCATAGTGAGTACGACAGGTTTACTTCTCAACACCGTACAAAGGGGAAAAGATAA
ATGCACCTTATCTCAATGAAAGCGATCCATGAAGCAGTTAACAGATACCCTCAGTATAAAAAAGAGCTTCTACAGTTTGG
TCGGAACATAGAGAAAGGTAATTGCCCTACCCCCGAAGAGCTGAAAAAAATCTATCCATCTCTGGATAATTTTAAATATC
TGGATAAACATTATGTTATTGATATTGCAAACAATAATATAAGAATTATCGCAATTGTTTTTTTCGAGAGTCAGAAGTTT
TATATTCGCCATGTATTCAACCATAGTGAGTACGACAGGTTTACTTCTCAACACCGTACAAAGGGGAAAAGATAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15251.55 Da Isoelectric Point: 4.6268
>AT78189 WP_223353941.1 NZ_CP022016:82194-82610 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MIVADALKATNALIAAVPLLGDNPDEKDYEEALELVEHLLMENPGSPLLDIVCNRIRTYEDGQPEIVALREEMNAIPVGL
AILRTLMDQYKLTTSDFQNEIGSKSMVSRVLNGKRNLSVNHIKKLSSRFGISPASFID
MIVADALKATNALIAAVPLLGDNPDEKDYEEALELVEHLLMENPGSPLLDIVCNRIRTYEDGQPEIVALREEMNAIPVGL
AILRTLMDQYKLTTSDFQNEIGSKSMVSRVLNGKRNLSVNHIKKLSSRFGISPASFID
Download Length: 417 bp
>AT78189 NZ_CP022016:82194-82610 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGATCGTTGCCGATGCACTTAAAGCGACCAATGCCCTTATAGCTGCCGTTCCTCTTCTGGGAGATAACCCTGACGAGAA
AGATTACGAAGAGGCCCTGGAACTTGTCGAACACCTGTTAATGGAGAATCCGGGTAGCCCTTTGCTGGATATCGTCTGTA
ATCGAATTCGTACCTATGAAGACGGTCAGCCTGAAATCGTTGCGCTCCGTGAAGAAATGAATGCTATCCCTGTGGGCCTT
GCGATTCTGCGGACGCTCATGGATCAGTACAAATTAACCACTTCTGATTTTCAAAATGAAATCGGTTCTAAATCAATGGT
ATCCCGCGTACTGAACGGAAAGCGCAATCTCAGCGTTAACCACATCAAAAAGCTGTCATCCCGGTTTGGTATATCCCCTG
CTTCGTTTATTGATTAA
ATGATCGTTGCCGATGCACTTAAAGCGACCAATGCCCTTATAGCTGCCGTTCCTCTTCTGGGAGATAACCCTGACGAGAA
AGATTACGAAGAGGCCCTGGAACTTGTCGAACACCTGTTAATGGAGAATCCGGGTAGCCCTTTGCTGGATATCGTCTGTA
ATCGAATTCGTACCTATGAAGACGGTCAGCCTGAAATCGTTGCGCTCCGTGAAGAAATGAATGCTATCCCTGTGGGCCTT
GCGATTCTGCGGACGCTCATGGATCAGTACAAATTAACCACTTCTGATTTTCAAAATGAAATCGGTTCTAAATCAATGGT
ATCCCGCGTACTGAACGGAAAGCGCAATCTCAGCGTTAACCACATCAAAAAGCTGTCATCCCGGTTTGGTATATCCCCTG
CTTCGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|