Detailed information of TA system TA078186

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4208372..4208974
• Replicon: chromosome
• Accession: NZ_CP022015
• Organism: Salmonella enterica subsp. enterica serovar India str. SA20085604

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: LFZ16_RS21140
• Protein ID: WP_001159630.1
• Coordinates: 4208372..4208683 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LFZ16_RS21145
• Protein ID: WP_000362050.1
• Coordinates: 4208684..4208974 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFZ16_RS21105 (4203485)	4203485..4204084	+	600	WP_000965695.1	glucose-1-phosphatase	-
LFZ16_RS21110 (4204078)	4204078..4204950	+	873	WP_000921423.1	virulence factor BrkB family protein	-
LFZ16_RS21115 (4204947)	4204947..4205384	+	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
LFZ16_RS21120 (4205429)	4205429..4206370	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LFZ16_RS21125 (4206385)	4206385..4206831	-	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
LFZ16_RS21130 (4206828)	4206828..4207139	-	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
LFZ16_RS21135 (4207225)	4207225..4208154	-	930	WP_023207327.1	alpha/beta hydrolase	-
LFZ16_RS21140 (4208372)	4208372..4208683	+	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LFZ16_RS21145 (4208684)	4208684..4208974	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LFZ16_RS21150 (4209021)	4209021..4209950	-	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
LFZ16_RS21155 (4209947)	4209947..4210582	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LFZ16_RS21160 (4210579)	4210579..4211481	-	903	WP_000331364.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T78186 WP_001159630.1 NZ_CP022015:4208372-4208683 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T78186 NZ_CP022015:4208372-4208683 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTACTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT78186 WP_000362050.1 NZ_CP022015:4208684-4208974 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT78186 NZ_CP022015:4208684-4208974 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGCTCACCGACAGGGCCAGCCAAAGCATTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64