Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2608072..2608634 | Replicon | chromosome |
| Accession | NZ_CP022015 | ||
| Organism | Salmonella enterica subsp. enterica serovar India str. SA20085604 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LFZ16_RS13245 | Protein ID | WP_223353586.1 |
| Coordinates | 2608072..2608350 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LFZ16_RS13250 | Protein ID | WP_223353588.1 |
| Coordinates | 2608350..2608634 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFZ16_RS13210 (2603242) | 2603242..2603475 | - | 234 | WP_223353578.1 | phage holin | - |
| LFZ16_RS13215 (2603734) | 2603734..2604231 | - | 498 | WP_223353579.1 | hypothetical protein | - |
| LFZ16_RS13220 (2604646) | 2604646..2604945 | - | 300 | WP_223353580.1 | STAS-like domain-containing protein | - |
| LFZ16_RS13225 (2604942) | 2604942..2605916 | - | 975 | WP_223353581.1 | hypothetical protein | - |
| LFZ16_RS13230 (2606055) | 2606055..2606816 | - | 762 | WP_223353582.1 | Bro-N domain-containing protein | - |
| LFZ16_RS13235 (2607072) | 2607072..2607413 | - | 342 | WP_223353583.1 | hypothetical protein | - |
| LFZ16_RS13240 (2607629) | 2607629..2607895 | - | 267 | WP_223353584.1 | hypothetical protein | - |
| LFZ16_RS13245 (2608072) | 2608072..2608350 | + | 279 | WP_223353586.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LFZ16_RS13250 (2608350) | 2608350..2608634 | + | 285 | WP_223353588.1 | HigA family addiction module antitoxin | Antitoxin |
| LFZ16_RS13255 (2608645) | 2608645..2609049 | - | 405 | WP_223353590.1 | antiterminator Q family protein | - |
| LFZ16_RS13260 (2609066) | 2609066..2609344 | - | 279 | WP_223353712.1 | hypothetical protein | - |
| LFZ16_RS13265 (2609352) | 2609352..2609549 | - | 198 | WP_223353592.1 | hypothetical protein | - |
| LFZ16_RS13270 (2609554) | 2609554..2610123 | - | 570 | WP_223353594.1 | DUF1367 family protein | - |
| LFZ16_RS13275 (2610128) | 2610128..2610283 | - | 156 | WP_223353596.1 | hypothetical protein | - |
| LFZ16_RS13280 (2610295) | 2610295..2610546 | - | 252 | WP_223353598.1 | hypothetical protein | - |
| LFZ16_RS13285 (2610543) | 2610543..2611907 | - | 1365 | WP_223353600.1 | replicative DNA helicase | - |
| LFZ16_RS13290 (2611904) | 2611904..2612860 | - | 957 | WP_223353602.1 | hypothetical protein | - |
| LFZ16_RS13295 (2612860) | 2612860..2613168 | - | 309 | WP_223353604.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | iroB / iroC / iroD / iroN / pipB2 / mig-14 / luxS | 2577341..2697148 | 119807 | |
| - | inside | Prophage | - | iroB / iroC / iroD / iroN / pipB2 / mig-14 / luxS | 2590922..2697148 | 106226 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10660.17 Da Isoelectric Point: 6.8698
>T78179 WP_223353586.1 NZ_CP022015:2608072-2608350 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MIKSFKHKGLKKFFLKNDSSGLEQHLVPRIQTRLTTIDAADTIEGIDIPNYELHQLKGDCKDIWSIKVSGNWRITFRFVD
GDAEIVNLEDYH
MIKSFKHKGLKKFFLKNDSSGLEQHLVPRIQTRLTTIDAADTIEGIDIPNYELHQLKGDCKDIWSIKVSGNWRITFRFVD
GDAEIVNLEDYH
Download Length: 279 bp
>T78179 NZ_CP022015:2608072-2608350 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGATTAAGAGCTTTAAGCACAAAGGACTTAAAAAGTTCTTTCTCAAAAATGACAGTAGCGGGCTTGAGCAACATCTGGT
TCCCCGCATACAAACACGACTGACTACTATTGACGCCGCTGACACTATCGAAGGTATCGACATACCAAACTACGAGTTGC
ATCAGCTAAAAGGTGATTGCAAAGACATATGGTCAATTAAAGTTTCCGGCAACTGGCGCATCACTTTCCGCTTTGTTGAT
GGTGATGCTGAAATTGTTAACCTGGAGGACTACCACTAA
ATGATTAAGAGCTTTAAGCACAAAGGACTTAAAAAGTTCTTTCTCAAAAATGACAGTAGCGGGCTTGAGCAACATCTGGT
TCCCCGCATACAAACACGACTGACTACTATTGACGCCGCTGACACTATCGAAGGTATCGACATACCAAACTACGAGTTGC
ATCAGCTAAAAGGTGATTGCAAAGACATATGGTCAATTAAAGTTTCCGGCAACTGGCGCATCACTTTCCGCTTTGTTGAT
GGTGATGCTGAAATTGTTAACCTGGAGGACTACCACTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10348.96 Da Isoelectric Point: 7.2770
>AT78179 WP_223353588.1 NZ_CP022015:2608350-2608634 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MKMANPAYPGQIIAETLEDLNVSVRQFAKAMEIAPSTASRLLSGQTAVTPEMAIRLSVVIGSTPETWLKIQSNYSLSEAR
EKVDIHHLHRLSCV
MKMANPAYPGQIIAETLEDLNVSVRQFAKAMEIAPSTASRLLSGQTAVTPEMAIRLSVVIGSTPETWLKIQSNYSLSEAR
EKVDIHHLHRLSCV
Download Length: 285 bp
>AT78179 NZ_CP022015:2608350-2608634 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGAAAATGGCTAACCCTGCATACCCTGGACAAATCATTGCTGAAACACTGGAAGATCTGAATGTAAGTGTTCGTCAGTT
TGCAAAAGCGATGGAAATTGCCCCATCCACAGCCAGCCGCCTCTTGTCCGGGCAGACTGCCGTAACGCCCGAAATGGCGA
TCAGGTTATCCGTCGTTATCGGCAGTACTCCCGAGACCTGGCTTAAAATTCAGTCCAACTACAGCCTCAGTGAAGCAAGG
GAGAAGGTGGATATTCATCATTTACATCGTCTGTCCTGTGTCTGA
ATGAAAATGGCTAACCCTGCATACCCTGGACAAATCATTGCTGAAACACTGGAAGATCTGAATGTAAGTGTTCGTCAGTT
TGCAAAAGCGATGGAAATTGCCCCATCCACAGCCAGCCGCCTCTTGTCCGGGCAGACTGCCGTAACGCCCGAAATGGCGA
TCAGGTTATCCGTCGTTATCGGCAGTACTCCCGAGACCTGGCTTAAAATTCAGTCCAACTACAGCCTCAGTGAAGCAAGG
GAGAAGGTGGATATTCATCATTTACATCGTCTGTCCTGTGTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|