Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HTH_XRE |
| Location | 345079..345671 | Replicon | chromosome |
| Accession | NZ_CP022015 | ||
| Organism | Salmonella enterica subsp. enterica serovar India str. SA20085604 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LFZ16_RS01740 | Protein ID | WP_223352938.1 |
| Coordinates | 345079..345357 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A5U9KVI5 |
| Locus tag | LFZ16_RS01745 | Protein ID | WP_053299568.1 |
| Coordinates | 345357..345671 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFZ16_RS01710 (340126) | 340126..341400 | + | 1275 | WP_223352932.1 | site-specific integrase | - |
| LFZ16_RS01715 (341578) | 341578..341982 | + | 405 | WP_223352933.1 | hypothetical protein | - |
| LFZ16_RS01720 (342497) | 342497..342937 | + | 441 | WP_223352934.1 | hypothetical protein | - |
| LFZ16_RS01725 (343125) | 343125..343568 | - | 444 | WP_223352935.1 | antiterminator Q family protein | - |
| LFZ16_RS01730 (344095) | 344095..344379 | + | 285 | WP_223352936.1 | DUF6516 family protein | - |
| LFZ16_RS01735 (344384) | 344384..344755 | + | 372 | WP_223352937.1 | transcriptional regulator | - |
| LFZ16_RS01740 (345079) | 345079..345357 | + | 279 | WP_223352938.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LFZ16_RS01745 (345357) | 345357..345671 | + | 315 | WP_053299568.1 | HigA family addiction module antitoxin | Antitoxin |
| LFZ16_RS01750 (345805) | 345805..346530 | + | 726 | WP_223352939.1 | hypothetical protein | - |
| LFZ16_RS01755 (346626) | 346626..346925 | + | 300 | WP_077944806.1 | AlpA family phage regulatory protein | - |
| LFZ16_RS01760 (346918) | 346918..347661 | + | 744 | WP_223352940.1 | antA/AntB antirepressor family protein | - |
| LFZ16_RS01765 (347710) | 347710..347880 | - | 171 | WP_223352941.1 | hypothetical protein | - |
| LFZ16_RS01770 (347884) | 347884..348066 | - | 183 | WP_223352942.1 | YlcI/YnfO family protein | - |
| LFZ16_RS01775 (348322) | 348322..348621 | - | 300 | WP_223352943.1 | BrnA antitoxin family protein | - |
| LFZ16_RS01780 (348581) | 348581..348853 | - | 273 | WP_223352944.1 | BrnT family toxin | - |
| LFZ16_RS01785 (348758) | 348758..349696 | + | 939 | WP_223352945.1 | ash family protein | - |
| LFZ16_RS01790 (349689) | 349689..349889 | + | 201 | WP_223352946.1 | hypothetical protein | - |
| LFZ16_RS01795 (349882) | 349882..350193 | + | 312 | WP_223352947.1 | hypothetical protein | - |
| LFZ16_RS01800 (350190) | 350190..350414 | + | 225 | WP_223352948.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 338945..365761 | 26816 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10826.30 Da Isoelectric Point: 9.3589
>T78175 WP_223352938.1 NZ_CP022015:345079-345357 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MIKSFRHKGLKQLFEKGITSGVPAQDVERINDRLQAIDTANEIGELNRKIYKLHPLKGDREGYWSITVRANWRITFQFIN
GDAYILNYEDYH
MIKSFRHKGLKQLFEKGITSGVPAQDVERINDRLQAIDTANEIGELNRKIYKLHPLKGDREGYWSITVRANWRITFQFIN
GDAYILNYEDYH
Download Length: 279 bp
>T78175 NZ_CP022015:345079-345357 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGATTAAATCATTCAGACATAAAGGGCTGAAACAGCTTTTCGAAAAAGGGATTACGTCTGGCGTACCCGCGCAGGATGT
CGAGCGGATTAACGACCGTTTACAGGCTATCGATACGGCAAATGAAATCGGCGAGTTAAACCGCAAAATATACAAGCTGC
ATCCGTTGAAAGGAGACCGGGAAGGTTACTGGTCCATTACGGTACGGGCTAACTGGCGCATTACTTTTCAGTTTATCAAT
GGTGATGCTTATATTCTGAATTACGAGGATTATCACTAA
ATGATTAAATCATTCAGACATAAAGGGCTGAAACAGCTTTTCGAAAAAGGGATTACGTCTGGCGTACCCGCGCAGGATGT
CGAGCGGATTAACGACCGTTTACAGGCTATCGATACGGCAAATGAAATCGGCGAGTTAAACCGCAAAATATACAAGCTGC
ATCCGTTGAAAGGAGACCGGGAAGGTTACTGGTCCATTACGGTACGGGCTAACTGGCGCATTACTTTTCAGTTTATCAAT
GGTGATGCTTATATTCTGAATTACGAGGATTATCACTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11501.18 Da Isoelectric Point: 7.2028
>AT78175 WP_053299568.1 NZ_CP022015:345357-345671 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MRQFKISHPGEIIARDLEDMGISGRRFALNIGVTPATVSRFLAGKTALTPAMAIRIAAALGSTPEFWLRLQSAYDLRQLE
NRIDTSQIALYGEQGDMQTVTPEH
MRQFKISHPGEIIARDLEDMGISGRRFALNIGVTPATVSRFLAGKTALTPAMAIRIAAALGSTPEFWLRLQSAYDLRQLE
NRIDTSQIALYGEQGDMQTVTPEH
Download Length: 315 bp
>AT78175 NZ_CP022015:345357-345671 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGAGACAGTTTAAGATTTCTCACCCCGGAGAGATTATTGCCAGGGATTTAGAGGATATGGGCATTAGTGGCCGCCGTTT
CGCGCTTAATATTGGCGTTACACCTGCCACGGTATCACGCTTTCTTGCAGGTAAAACCGCGCTTACCCCGGCTATGGCGA
TCCGCATTGCCGCAGCGCTGGGAAGTACGCCGGAGTTCTGGCTGAGACTTCAAAGCGCTTACGATTTGCGCCAACTGGAA
AACCGGATTGATACATCGCAGATCGCTTTATATGGCGAACAGGGCGACATGCAGACGGTCACGCCTGAACATTAA
ATGAGACAGTTTAAGATTTCTCACCCCGGAGAGATTATTGCCAGGGATTTAGAGGATATGGGCATTAGTGGCCGCCGTTT
CGCGCTTAATATTGGCGTTACACCTGCCACGGTATCACGCTTTCTTGCAGGTAAAACCGCGCTTACCCCGGCTATGGCGA
TCCGCATTGCCGCAGCGCTGGGAAGTACGCCGGAGTTCTGGCTGAGACTTCAAAGCGCTTACGATTTGCGCCAACTGGAA
AACCGGATTGATACATCGCAGATCGCTTTATATGGCGAACAGGGCGACATGCAGACGGTCACGCCTGAACATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|