Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2979855..2980503 Replicon chromosome
Accession NZ_CP022014
Organism Mycobacterium tuberculosis strain MTB2

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag B7R63_RS14550 Protein ID WP_003899414.1
Coordinates 2979855..2980178 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag B7R63_RS14555 Protein ID WP_003899415.1
Coordinates 2980258..2980503 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7R63_RS14520 2975178..2976176 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
B7R63_RS14525 2976190..2976654 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
B7R63_RS14530 2976642..2976893 + 252 WP_003908028.1 hypothetical protein -
B7R63_RS14535 2977064..2978503 - 1440 WP_003901443.1 phage major capsid protein -
B7R63_RS14540 2978511..2979044 - 534 WP_003899412.1 HK97 family phage prohead protease -
B7R63_RS14545 2979197..2979688 - 492 WP_003900541.1 phage terminase small subunit P27 family -
B7R63_RS14550 2979855..2980178 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
B7R63_RS14555 2980258..2980503 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
B7R63_RS14560 2980500..2981927 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
B7R63_RS14565 2981929..2982321 - 393 WP_003899417.1 DUF2742 domain-containing protein -
B7R63_RS14570 2982318..2982578 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
B7R63_RS14575 2982595..2982957 - 363 WP_003900543.1 hypothetical protein -
B7R63_RS14580 2982960..2984087 - 1128 WP_003899420.1 site-specific integrase -
B7R63_RS14585 2984232..2984459 - 228 WP_003899421.1 hypothetical protein -
B7R63_RS14590 2984456..2984845 - 390 WP_003899422.1 hypothetical protein -
B7R63_RS14595 2984751..2985023 + 273 WP_003900544.1 hypothetical protein -
B7R63_RS14600 2985122..2985355 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2975178..2984087 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T78163 WP_003899414.1 NZ_CP022014:c2980178-2979855 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T78163 NZ_CP022014:c2980178-2979855 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT78163 WP_003899415.1 NZ_CP022014:c2980503-2980258 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT78163 NZ_CP022014:c2980503-2980258 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References