Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 178007..178639 Replicon chromosome
Accession NZ_CP022013
Organism Mergibacter septicus strain 27517-4-I1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CEP47_RS00900 Protein ID WP_261919844.1
Coordinates 178334..178639 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CEP47_RS00895 Protein ID WP_261919845.1
Coordinates 178007..178324 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP47_RS00850 (CEP47_00850) 173267..174172 - 906 WP_261919852.1 hypothetical protein -
CEP47_RS00855 (CEP47_00855) 174270..174965 - 696 WP_261919851.1 helix-turn-helix transcriptional regulator -
CEP47_RS00860 (CEP47_00860) 175085..175285 + 201 WP_261919850.1 YdaS family helix-turn-helix protein -
CEP47_RS00865 (CEP47_00865) 175334..175774 + 441 WP_261919849.1 YmfL family putative regulatory protein -
CEP47_RS00870 (CEP47_00870) 175819..176013 + 195 WP_261919848.1 hypothetical protein -
CEP47_RS00875 (CEP47_00875) 176003..176248 + 246 WP_261919847.1 helix-turn-helix domain-containing protein -
CEP47_RS00880 (CEP47_00880) 176483..176896 + 414 Protein_158 ATP-binding protein -
CEP47_RS00885 (CEP47_00885) 176939..177366 + 428 Protein_159 recombination protein NinB -
CEP47_RS00890 (CEP47_00890) 177404..177733 - 330 Protein_160 bacteriocin -
CEP47_RS00895 (CEP47_00895) 178007..178324 - 318 WP_261919845.1 HigA family addiction module antitoxin Antitoxin
CEP47_RS00900 (CEP47_00900) 178334..178639 - 306 WP_261919844.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEP47_RS00905 (CEP47_00905) 178716..179306 + 591 WP_261919843.1 recombination protein NinG -
CEP47_RS00910 (CEP47_00910) 179306..179713 + 408 WP_261919842.1 hypothetical protein -
CEP47_RS00915 (CEP47_00915) 179799..179996 + 198 WP_261919841.1 type II toxin-antitoxin system HicA family toxin -
CEP47_RS00920 (CEP47_00920) 180048..180398 + 351 WP_261919840.1 type II toxin-antitoxin system HicB family antitoxin -
CEP47_RS00925 (CEP47_00925) 180542..180778 + 237 WP_261919839.1 hypothetical protein -
CEP47_RS00930 (CEP47_00930) 181027..181665 - 639 WP_261919838.1 nitroreductase family protein -
CEP47_RS00935 (CEP47_00935) 181689..182870 - 1182 WP_261919837.1 iron-containing alcohol dehydrogenase -
CEP47_RS00940 (CEP47_00940) 182954..183544 - 591 WP_261919836.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 166992..190906 23914


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-99)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12119.80 Da        Isoelectric Point: 9.2439

>T78110 WP_261919844.1 NZ_CP022013:c178639-178334 [Mergibacter septicus]
MFNLTQAHFRDNYLYRFFQYGEAHSKIPSNLTNVLARKLDMINVAENLNDLRVPPANRLDLLEPKDNKRYSIRVNKQYRL
IFKFENGEIADLYLDPHRYDV

Download         Length: 306 bp

>T78110 NZ_CP022013:c178639-178334 [Mergibacter septicus]
ATGTTTAACCTTACACAAGCACATTTTCGTGATAATTACCTGTATCGTTTTTTCCAATATGGTGAGGCACACAGTAAAAT
TCCCTCAAATTTAACTAATGTGCTGGCACGCAAACTGGATATGATCAATGTGGCTGAAAATCTCAACGATTTACGTGTGC
CACCTGCAAATCGACTTGATTTGCTTGAGCCCAAAGACAACAAACGCTATTCAATTCGTGTTAATAAGCAATACCGCCTG
ATTTTCAAATTTGAAAACGGCGAGATTGCCGATTTATATTTAGATCCCCATCGTTATGATGTATAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11802.63 Da        Isoelectric Point: 7.0114

>AT78110 WP_261919845.1 NZ_CP022013:c178324-178007 [Mergibacter septicus]
MLAMQRKPTPVGEILQAEFLEPLNLKIGDLAIILNVHRNTASSLVNNSSRVTLEMAVKLSKAFGTTPEFWLNLQNNVDLW
ELNNNPRFQQSLEKVQIANNVAFAL

Download         Length: 318 bp

>AT78110 NZ_CP022013:c178324-178007 [Mergibacter septicus]
ATGTTAGCTATGCAACGCAAACCCACCCCAGTAGGAGAAATCTTACAAGCTGAATTTCTTGAGCCGTTAAACCTTAAAAT
TGGTGATTTAGCGATAATTCTTAATGTTCATCGCAATACCGCAAGTAGCCTTGTCAATAATAGCTCTCGTGTTACCCTTG
AAATGGCGGTAAAACTCTCTAAAGCCTTTGGCACAACACCTGAGTTCTGGCTCAACTTGCAAAACAACGTGGATTTATGG
GAACTCAACAACAACCCACGCTTTCAACAAAGCCTTGAGAAAGTACAAATCGCAAATAACGTTGCCTTTGCACTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References