78096

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 865843..866463 Replicon chromosome
Accession NZ_CP022006
Organism Burkholderia gladioli pv. gladioli strain KACC 11889

Toxin (Protein)


Gene name higB Uniprot ID A0A808W391
Locus tag CEJ98_RS24520 Protein ID WP_036056413.1
Coordinates 865843..866121 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A808W2D6
Locus tag CEJ98_RS24525 Protein ID WP_036056415.1
Coordinates 866140..866463 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEJ98_RS24495 860905..861507 + 603 WP_036056407.1 TetR/AcrR family transcriptional regulator -
CEJ98_RS24500 861700..862800 + 1101 WP_036056409.1 helix-turn-helix transcriptional regulator -
CEJ98_RS24505 862949..863671 + 723 WP_013690208.1 fumarylacetoacetate hydrolase family protein -
CEJ98_RS24510 863945..864814 + 870 WP_036056411.1 CPBP family intramembrane metalloprotease -
CEJ98_RS24515 864932..865600 - 669 WP_025100406.1 NAAT family transporter -
CEJ98_RS24520 865843..866121 + 279 WP_036056413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEJ98_RS24525 866140..866463 + 324 WP_036056415.1 HigA family addiction module antidote protein Antitoxin
CEJ98_RS24530 866571..867656 + 1086 WP_036056417.1 ionic transporter y4hA -
CEJ98_RS24535 867699..868655 - 957 WP_036056420.1 LysR family transcriptional regulator -
CEJ98_RS24540 869049..870227 + 1179 WP_036056422.1 HPP family protein -
CEJ98_RS24545 870335..870748 + 414 WP_013690200.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(11-91)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10301.87 Da        Isoelectric Point: 9.2604

>T78096 WP_036056413.1 NZ_CP022006:865843-866121 [Burkholderia gladioli pv. gladioli]
MIQSFRCKRTAALFAGESPPAWGAVAQVARRKLAMLDAAQALRDLAVPPGNQLEGLFGDRAGQYSIRINERWRLCFVWSS
RGPELVEIVDYH

Download         Length: 279 bp

>T78096 NZ_CP022006:865843-866121 [Burkholderia gladioli pv. gladioli]
ATGATCCAGTCATTCCGATGCAAGCGCACCGCCGCGCTGTTCGCCGGCGAATCGCCGCCGGCCTGGGGTGCCGTGGCACA
AGTGGCCCGGCGCAAGCTGGCCATGCTCGATGCGGCCCAGGCGCTGCGCGACCTGGCCGTGCCGCCCGGCAACCAACTCG
AAGGCCTGTTCGGCGATCGCGCGGGGCAATACAGCATCCGGATCAACGAGCGCTGGCGCCTTTGTTTCGTCTGGAGCAGC
CGGGGGCCCGAGCTCGTCGAGATCGTCGATTACCACTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11906.72 Da        Isoelectric Point: 7.2024

>AT78096 WP_036056415.1 NZ_CP022006:866140-866463 [Burkholderia gladioli pv. gladioli]
MNAKSVKPVNAMPAIHPGEILREEFLVPLALSVNALSLALMVPATRMHEIVNERRGITADTAYRLSRYFGTTPEFWLALQ
ADYDIKTLPNRDEIDRKVDARSTGAAP

Download         Length: 324 bp

>AT78096 NZ_CP022006:866140-866463 [Burkholderia gladioli pv. gladioli]
ATGAATGCCAAGAGTGTGAAGCCCGTCAACGCGATGCCCGCCATCCACCCCGGCGAAATCCTGCGCGAGGAGTTCCTGGT
GCCGCTCGCGCTCAGCGTCAACGCGCTGTCGCTGGCGCTGATGGTGCCGGCCACCCGCATGCACGAGATCGTCAACGAGC
GGCGCGGCATCACCGCCGACACGGCCTACCGCCTGTCGCGCTACTTCGGCACCACGCCGGAGTTCTGGCTGGCCCTGCAG
GCCGACTACGACATCAAGACCCTGCCGAACCGCGACGAGATCGACCGCAAGGTCGATGCGCGCTCCACCGGCGCGGCGCC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808W391

Antitoxin

Source ID Structure
AlphaFold DB A0A808W2D6

References