Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1546116..1546711 Replicon chromosome
Accession NZ_CP022002
Organism Pseudomonas aeruginosa strain Pa1242

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CD799_RS07290 Protein ID WP_079752024.1
Coordinates 1546116..1546394 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CD799_RS07295 Protein ID WP_083556829.1
Coordinates 1546406..1546711 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD799_RS07260 1541421..1541873 + 453 WP_088376613.1 ribosomal protein S18-alanine N-acetyltransferase -
CD799_RS07265 1542072..1543310 + 1239 WP_088376614.1 C69 family dipeptidase -
CD799_RS07270 1543372..1544022 + 651 WP_033971066.1 carbonate dehydratase -
CD799_RS07275 1544329..1544844 + 516 WP_033971063.1 hypothetical protein -
CD799_RS07280 1545266..1545469 - 204 WP_033971061.1 hypothetical protein -
CD799_RS07285 1545837..1546063 + 227 Protein_1407 tyrosine-type recombinase/integrase -
CD799_RS07290 1546116..1546394 + 279 WP_079752024.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CD799_RS07295 1546406..1546711 + 306 WP_083556829.1 HigA family addiction module antidote protein Antitoxin
CD799_RS07305 1547104..1548204 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
CD799_RS07310 1548245..1548829 - 585 WP_033971054.1 aminoacyl-tRNA hydrolase -
CD799_RS07315 1548871..1549485 - 615 WP_033971050.1 50S ribosomal protein L25/general stress protein Ctc -
CD799_RS07320 1549602..1550543 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
CD799_RS07330 1550710..1551558 - 849 WP_088376615.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10673.26 Da        Isoelectric Point: 8.5538

>T78086 WP_079752024.1 NZ_CP022002:1546116-1546394 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAAKELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T78086 NZ_CP022002:1546116-1546394 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAAGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11243.78 Da        Isoelectric Point: 4.7860

>AT78086 WP_083556829.1 NZ_CP022002:1546406-1546711 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELKISPTALARALNVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT78086 NZ_CP022002:1546406-1546711 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGAAGATCTCTCC
AACTGCTCTAGCACGCGCTTTGAACGTCTCCGCCCCGACAGTGAACGATATTGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGCCTGGGGCGTTACTTTGACACGTCCGCTCAGTTCTGGATGAATCTTCAGAGTGAGTATTCGTTGGCA
ACTGCTTATGCGGCGAACGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References