Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 1546116..1546711 | Replicon | chromosome |
Accession | NZ_CP022002 | ||
Organism | Pseudomonas aeruginosa strain Pa1242 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | CD799_RS07290 | Protein ID | WP_079752024.1 |
Coordinates | 1546116..1546394 (+) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | CD799_RS07295 | Protein ID | WP_083556829.1 |
Coordinates | 1546406..1546711 (+) | Length | 102 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CD799_RS07260 | 1541421..1541873 | + | 453 | WP_088376613.1 | ribosomal protein S18-alanine N-acetyltransferase | - |
CD799_RS07265 | 1542072..1543310 | + | 1239 | WP_088376614.1 | C69 family dipeptidase | - |
CD799_RS07270 | 1543372..1544022 | + | 651 | WP_033971066.1 | carbonate dehydratase | - |
CD799_RS07275 | 1544329..1544844 | + | 516 | WP_033971063.1 | hypothetical protein | - |
CD799_RS07280 | 1545266..1545469 | - | 204 | WP_033971061.1 | hypothetical protein | - |
CD799_RS07285 | 1545837..1546063 | + | 227 | Protein_1407 | tyrosine-type recombinase/integrase | - |
CD799_RS07290 | 1546116..1546394 | + | 279 | WP_079752024.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
CD799_RS07295 | 1546406..1546711 | + | 306 | WP_083556829.1 | HigA family addiction module antidote protein | Antitoxin |
CD799_RS07305 | 1547104..1548204 | - | 1101 | WP_003099270.1 | redox-regulated ATPase YchF | - |
CD799_RS07310 | 1548245..1548829 | - | 585 | WP_033971054.1 | aminoacyl-tRNA hydrolase | - |
CD799_RS07315 | 1548871..1549485 | - | 615 | WP_033971050.1 | 50S ribosomal protein L25/general stress protein Ctc | - |
CD799_RS07320 | 1549602..1550543 | - | 942 | WP_003099281.1 | ribose-phosphate pyrophosphokinase | - |
CD799_RS07330 | 1550710..1551558 | - | 849 | WP_088376615.1 | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10673.26 Da Isoelectric Point: 8.5538
>T78086 WP_079752024.1 NZ_CP022002:1546116-1546394 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAAKELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAAKELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
Download Length: 279 bp
>T78086 NZ_CP022002:1546116-1546394 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAAGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAAGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11243.78 Da Isoelectric Point: 4.7860
>AT78086 WP_083556829.1 NZ_CP022002:1546406-1546711 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELKISPTALARALNVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG
MATNGMRPIHPGEILRDEFLMELKISPTALARALNVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG
Download Length: 306 bp
>AT78086 NZ_CP022002:1546406-1546711 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGAAGATCTCTCC
AACTGCTCTAGCACGCGCTTTGAACGTCTCCGCCCCGACAGTGAACGATATTGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGCCTGGGGCGTTACTTTGACACGTCCGCTCAGTTCTGGATGAATCTTCAGAGTGAGTATTCGTTGGCA
ACTGCTTATGCGGCGAACGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGAAGATCTCTCC
AACTGCTCTAGCACGCGCTTTGAACGTCTCCGCCCCGACAGTGAACGATATTGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGCCTGGGGCGTTACTTTGACACGTCCGCTCAGTTCTGGATGAATCTTCAGAGTGAGTATTCGTTGGCA
ACTGCTTATGCGGCGAACGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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