Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5542901..5543496 Replicon chromosome
Accession NZ_CP021999
Organism Pseudomonas aeruginosa strain Pa84

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag CD796_RS26670 Protein ID WP_003113526.1
Coordinates 5543218..5543496 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CD796_RS26665 Protein ID WP_003133769.1
Coordinates 5542901..5543206 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD796_RS26630 5538041..5538889 + 849 WP_003162406.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
CD796_RS26640 5539056..5539997 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
CD796_RS26645 5540114..5540728 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
CD796_RS26650 5540770..5541354 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
CD796_RS26655 5541395..5542495 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
CD796_RS26665 5542901..5543206 - 306 WP_003133769.1 HigA family addiction module antidote protein Antitoxin
CD796_RS26670 5543218..5543496 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CD796_RS26680 5543825..5546053 + 2229 WP_088407269.1 TonB-dependent receptor -
CD796_RS26685 5546123..5546770 - 648 WP_003095021.1 carbonate dehydratase -
CD796_RS26690 5546832..5548070 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T78066 WP_003113526.1 NZ_CP021999:c5543496-5543218 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T78066 NZ_CP021999:c5543496-5543218 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT78066 WP_003133769.1 NZ_CP021999:c5543206-5542901 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT78066 NZ_CP021999:c5543206-5542901 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGACACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCCCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References