Detailed information of TA system TA078049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 4161708..4162404
• Replicon: chromosome
• Accession: NZ_CP021971
• Organism: Hafnia alvei strain CBA7135

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A4Q9EV19
• Locus tag: CD201_RS19095
• Protein ID: WP_043489473.1
• Coordinates: 4162093..4162404 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: CD201_RS19090
• Protein ID: WP_043489471.1
• Coordinates: 4161708..4162106 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CD201_RS19080	4157404..4159851	+	2448	WP_025799360.1	glycogen phosphorylase	-
CD201_RS19085	4159981..4161465	-	1485	WP_025799362.1	glycerol-3-phosphate dehydrogenase	-
CD201_RS19090	4161708..4162106	-	399	WP_043489471.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CD201_RS19095	4162093..4162404	-	312	WP_043489473.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CD201_RS19100	4162660..4163418	-	759	WP_025799366.1	DeoR/GlpR family transcriptional regulator	-
CD201_RS19105	4163465..4164301	-	837	WP_043489475.1	rhomboid family intramembrane serine protease GlpG	-
CD201_RS19110	4164349..4164678	-	330	WP_025799370.1	thiosulfate sulfurtransferase GlpE	-
CD201_RS19115	4164952..4165383	+	432	WP_043489478.1	hypothetical protein	-
CD201_RS19120	4165519..4166277	-	759	WP_025799373.1	glycerophosphodiester phosphodiesterase	-
CD201_RS19125	4166311..4167387	-	1077	WP_111330657.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12053.05 Da
• Isoelectric Point: 8.2604

>T78049 WP_043489473.1 NZ_CP021971:c4162404-4162093 [Hafnia alvei]
MEKRTPHCSLEKVRNLIGKGMIKATKVAYLNAKRLDFSCADMYRVVSELSAKDFYKSMTTYQNHKIWQDVYHCHLEKVSL
YLKLTVVDEVLIVSFKELDDDMS

Nucleotide

• Length: 312 bp

>T78049 NZ_CP021971:c4162404-4162093 [Hafnia alvei]
ATGGAGAAGCGAACGCCGCATTGTAGCTTGGAAAAGGTACGGAACTTGATTGGGAAGGGGATGATTAAAGCCACAAAAGT
CGCTTATTTGAATGCGAAGCGCCTCGATTTTAGCTGTGCAGATATGTATCGAGTCGTGAGTGAGTTATCTGCTAAAGACT
TTTATAAAAGTATGACAACGTATCAAAACCACAAAATTTGGCAGGATGTGTACCACTGCCATCTGGAAAAGGTATCTCTC
TATCTGAAACTAACGGTAGTGGATGAAGTGTTAATCGTGTCTTTTAAGGAGCTAGATGATGATATGTCCTGA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14872.07 Da
• Isoelectric Point: 4.9755

>AT78049 WP_043489471.1 NZ_CP021971:c4162106-4161708 [Hafnia alvei]
MICPECGSSNTVKEYRDTPYTYKGQTMIIKAWGADWCLDCGEGVIFKEESLRIDSILTEFNKQVNASIIDPEYVVAMRKK
LNLSQSEAGEIFGGGVNAFSRYETGKALPHVSTIKLLKLLDKYPELLEEIRN

Nucleotide

• Length: 399 bp

>AT78049 NZ_CP021971:c4162106-4161708 [Hafnia alvei]
ATGATATGTCCTGAATGTGGATCGTCCAACACGGTGAAGGAGTACCGTGATACTCCCTACACCTATAAAGGCCAAACGAT
GATAATCAAGGCATGGGGCGCTGACTGGTGTTTAGACTGCGGGGAAGGTGTGATTTTTAAAGAAGAATCTCTGCGTATCG
ACAGCATTTTGACGGAGTTCAACAAGCAGGTTAATGCTTCCATCATCGATCCTGAGTACGTGGTGGCAATGCGAAAAAAG
CTGAACCTTTCCCAAAGTGAAGCCGGTGAGATCTTTGGCGGCGGTGTGAACGCATTTTCGCGCTACGAAACAGGCAAAGC
GCTGCCCCATGTATCGACCATCAAGTTGTTAAAATTACTTGATAAATATCCAGAATTGCTCGAAGAAATTCGTAACTAG

Structures

Toxin

• AlphaFold DB: A0A4Q9EV19