Detailed information of TA system TA077856

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-sprA1AS/-
• Location: 2194850..2195047
• Replicon: chromosome
• Accession: NZ_CP021907
• Organism: Staphylococcus aureus strain Seattle 1945 isolate G478

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: -
• Locus tag: CD795_RS11235
• Protein ID: WP_073392962.1
• Coordinates: 2194943..2195047 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2194850..2194888 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CD795_RS11215	2191025..2191690	-	666	WP_001024099.1	SDR family oxidoreductase	-
CD795_RS11220	2191842..2192162	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
CD795_RS11225	2192164..2193144	+	981	WP_000019741.1	CDF family zinc efflux transporter CzrB	-
CD795_RS11230	2193410..2194501	+	1092	WP_000495684.1	hypothetical protein	-
-	2194850..2194888	+	39	-	-	Antitoxin
CD795_RS11235	2194943..2195047	-	105	WP_073392962.1	hypothetical protein	Toxin
CD795_RS11245	2195727..2195885	+	159	WP_001792784.1	hypothetical protein	-
CD795_RS11255	2196544..2197401	-	858	WP_000370937.1	Cof-type HAD-IIB family hydrolase	-
CD795_RS11260	2197469..2198251	-	783	WP_000908186.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-113)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3920.80 Da
• Isoelectric Point: 5.5724

>T77856 WP_073392962.1 NZ_CP021907:c2195047-2194943 [Staphylococcus aureus]
MLLLERTSMSDFEMLMIVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T77856 NZ_CP021907:c2195047-2194943 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGATTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT77856 NZ_CP021907:2194850-2194888 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Antitoxin