Detailed information of TA system TA077848

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 974320..974569
• Replicon: chromosome
• Accession: NZ_CP021907
• Organism: Staphylococcus aureus strain Seattle 1945 isolate G478

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: CD795_RS04785
• Protein ID: WP_000623369.1
• Coordinates: 974320..974427 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	974422..974569 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CD795_RS04760	970993..971562	-	570	WP_000287265.1	competence protein ComK	-
CD795_RS04765	971772..971990	+	219	WP_000876825.1	IDEAL domain-containing protein	-
CD795_RS04770	972071..973057	-	987	WP_000668822.1	lipoate--protein ligase	-
CD795_RS04775	973256..973432	+	177	WP_000214898.1	YkvS family protein	-
CD795_RS04780	973447..974049	+	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
CD795_RS04785	974320..974427	+	108	WP_000623369.1	putative holin-like toxin	Toxin
-	974422..974569	-	148	-	-	Antitoxin
CD795_RS04790	974966..975067	+	102	WP_001790623.1	hypothetical protein	-
CD795_RS04795	975077..975349	+	273	WP_001794574.1	lactococcin 972 family bacteriocin	-
CD795_RS04800	975393..977357	+	1965	WP_000870820.1	bacteriocin-associated integral membrane family protein	-
CD795_RS04805	977360..977680	+	321	WP_000873929.1	YxeA family protein	-
CD795_RS04810	977677..978318	+	642	WP_000571183.1	ABC transporter ATP-binding protein	-
CD795_RS04815	978406..978696	-	291	WP_001791476.1	hypothetical protein	-
CD795_RS04820	979037..979324	+	288	WP_000410718.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	sspC / sspB / sspA	971664..1008341	36677

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T77848 WP_000623369.1 NZ_CP021907:974320-974427 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

>T77848 NZ_CP021907:974320-974427 [Staphylococcus aureus]
GTGATATCTATTGCAAACGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 148 bp

>AT77848 NZ_CP021907:c974569-974422 [Staphylococcus aureus]
CAATTAAATAAAAGATATGTTACTATAAAAATGTAAAAAGACGACATGCAGGAACATGTCGCCTAATGAGCCCGTTAAAA
AGACGGTGACTAAATGAGATTTTCTTTAACCATCATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Structures

Antitoxin