Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2497906..2498429 Replicon chromosome
Accession NZ_CP021905
Organism Staphylococcus aureus strain Seattle 1945 isolate G477

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag CD017_RS12870 Protein ID WP_000074047.1
Coordinates 2497906..2498172 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag CD017_RS12875 Protein ID WP_000587617.1
Coordinates 2498172..2498429 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD017_RS12850 2493116..2494303 - 1188 WP_000026190.1 MFS transporter -
CD017_RS12855 2494697..2495473 - 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
CD017_RS12860 2495466..2496128 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
CD017_RS12865 2496474..2497550 - 1077 WP_001076679.1 M42 family metallopeptidase -
CD017_RS12870 2497906..2498172 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
CD017_RS12875 2498172..2498429 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CD017_RS12885 2498789..2499244 + 456 WP_000732090.1 YehR family lipoprotein -
CD017_RS12890 2499412..2500989 - 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
CD017_RS12895 2501185..2501934 + 750 WP_000072447.1 CPBP family intramembrane metalloprotease -
CD017_RS12900 2502158..2503351 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T77845 WP_000074047.1 NZ_CP021905:c2498172-2497906 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T77845 NZ_CP021905:c2498172-2497906 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGATCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT77845 WP_000587617.1 NZ_CP021905:c2498429-2498172 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT77845 NZ_CP021905:c2498429-2498172 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References