Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2441290..2441807 Replicon chromosome
Accession NZ_CP021905
Organism Staphylococcus aureus strain Seattle 1945 isolate G477

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag CD017_RS12570 Protein ID WP_000251928.1
Coordinates 2441290..2441556 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag CD017_RS12575 Protein ID WP_000584497.1
Coordinates 2441556..2441807 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD017_RS12545 2436498..2437034 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
CD017_RS12550 2437501..2438325 - 825 WP_000594640.1 formate/nitrite transporter family protein -
CD017_RS12555 2438528..2438710 - 183 WP_000079140.1 hypothetical protein -
CD017_RS12560 2438797..2439264 - 468 WP_000153340.1 SRPBCC domain-containing protein -
CD017_RS12565 2439450..2440997 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CD017_RS12570 2441290..2441556 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
CD017_RS12575 2441556..2441807 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CD017_RS12580 2441971..2442071 - 101 Protein_2338 hypothetical protein -
CD017_RS12585 2442078..2442677 - 600 WP_000162804.1 DsbA family protein -
CD017_RS12590 2442696..2443058 - 363 WP_000819843.1 DUF4467 domain-containing protein -
CD017_RS12595 2443313..2444563 + 1251 Protein_2341 FemA/FemB family glycyltransferase FmhA -
CD017_RS12600 2444660..2445391 - 732 WP_000615465.1 amino acid ABC transporter ATP-binding protein -
CD017_RS12605 2445388..2446107 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T77842 WP_000251928.1 NZ_CP021905:c2441556-2441290 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T77842 NZ_CP021905:c2441556-2441290 [Staphylococcus aureus]
ATGGTTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCGTTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT77842 WP_000584497.1 NZ_CP021905:c2441807-2441556 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT77842 NZ_CP021905:c2441807-2441556 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATAGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References