Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1943683..1944340 Replicon chromosome
Accession NZ_CP021902
Organism Enterobacter cloacae complex sp. strain AR_0136

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AM383_RS10400 Protein ID WP_032609983.1
Coordinates 1943683..1943982 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AM383_RS10405 Protein ID WP_032609984.1
Coordinates 1943993..1944340 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM383_RS10390 (AM383_10300) 1940060..1942252 + 2193 WP_032609980.1 type I secretion system permease/ATPase -
AM383_RS10395 (AM383_10305) 1942233..1943432 + 1200 WP_032609982.1 HlyD family efflux transporter periplasmic adaptor subunit -
AM383_RS10400 (AM383_10310) 1943683..1943982 + 300 WP_032609983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM383_RS10405 (AM383_10315) 1943993..1944340 + 348 WP_032609984.1 HigA family addiction module antitoxin Antitoxin
AM383_RS10410 (AM383_10320) 1944416..1945597 - 1182 WP_023314694.1 PLP-dependent aminotransferase family protein -
AM383_RS10415 (AM383_10325) 1945618..1946505 - 888 WP_022651703.1 LysR family transcriptional regulator -
AM383_RS10420 (AM383_10330) 1946603..1947205 + 603 WP_022651704.1 short chain dehydrogenase -
AM383_RS10425 (AM383_10335) 1947202..1947933 - 732 WP_022651705.1 class I SAM-dependent methyltransferase -
AM383_RS10430 (AM383_10340) 1948008..1949006 - 999 WP_022651706.1 transketolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-103)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11610.24 Da        Isoelectric Point: 9.6776

>T77818 WP_032609983.1 NZ_CP021902:1943683-1943982 [Enterobacter cloacae complex sp.]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNIYEALSPTLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T77818 NZ_CP021902:1943683-1943982 [Enterobacter cloacae complex sp.]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TATATGAAGCATTGAGTCCTACGTTGAAGGGATACTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13094.06 Da        Isoelectric Point: 9.5932

>AT77818 WP_032609984.1 NZ_CP021902:1943993-1944340 [Enterobacter cloacae complex sp.]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEVLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWETQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT77818 NZ_CP021902:1943993-1944340 [Enterobacter cloacae complex sp.]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGGTGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAACGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCGGACGTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References