Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2072722..2073415 Replicon chromosome
Accession NZ_CP021879
Organism Escherichia coli strain AR_0137

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag AM384_RS10665 Protein ID WP_000415584.1
Coordinates 2072722..2073018 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag AM384_RS10670 Protein ID WP_000650107.1
Coordinates 2073020..2073415 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM384_RS10625 2067810..2068124 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
AM384_RS10630 2068155..2068736 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
AM384_RS10640 2069055..2069387 + 333 WP_023149630.1 DUF2645 family protein -
AM384_RS10645 2069433..2070782 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
AM384_RS10650 2070779..2071438 - 660 WP_001221493.1 two-component system response regulator QseB -
AM384_RS10655 2071590..2071982 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
AM384_RS10660 2072035..2072517 + 483 WP_000183505.1 transcriptional regulator -
AM384_RS10665 2072722..2073018 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
AM384_RS10670 2073020..2073415 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
AM384_RS10675 2073548..2075155 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
AM384_RS10680 2075293..2077551 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T77757 WP_000415584.1 NZ_CP021879:2072722-2073018 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T77757 NZ_CP021879:2072722-2073018 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT77757 WP_000650107.1 NZ_CP021879:2073020-2073415 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT77757 NZ_CP021879:2073020-2073415 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References