Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1952944..1953457 Replicon chromosome
Accession NZ_CP021868
Organism Streptococcus agalactiae strain SG-M8

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag BB159_RS10025 Protein ID WP_000481712.1
Coordinates 1952944..1953198 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag BB159_RS10030 Protein ID WP_000387490.1
Coordinates 1953191..1953457 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB159_RS10005 1948716..1951217 - 2502 WP_192866797.1 ATP-binding protein -
BB159_RS10010 1951238..1951648 - 411 WP_000390748.1 conjugal transfer protein -
BB159_RS10015 1951652..1951918 - 267 WP_001055036.1 hypothetical protein -
BB159_RS10020 1951938..1952891 - 954 WP_088181621.1 conjugal transfer protein -
BB159_RS10025 1952944..1953198 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
BB159_RS10030 1953191..1953457 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BB159_RS10035 1953602..1954075 - 474 WP_000560386.1 hypothetical protein -
BB159_RS10040 1954083..1954565 - 483 WP_088181622.1 antirestriction protein ArdA -
BB159_RS10045 1954617..1954889 - 273 WP_000072642.1 hypothetical protein -
BB159_RS10050 1955021..1955374 - 354 WP_000571928.1 helix-turn-helix domain-containing protein -
BB159_RS10055 1955367..1955582 - 216 WP_001897988.1 helix-turn-helix domain-containing protein -
BB159_RS10060 1955566..1955943 - 378 WP_000287184.1 hypothetical protein -
BB159_RS10065 1955959..1957191 - 1233 WP_000338840.1 replication initiation factor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T77732 WP_000481712.1 NZ_CP021868:c1953198-1952944 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T77732 NZ_CP021868:c1953198-1952944 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT77732 WP_000387490.1 NZ_CP021868:c1953457-1953191 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT77732 NZ_CP021868:c1953457-1953191 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References