Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 57941..58587 Replicon chromosome
Accession NZ_CP021851
Organism Enterobacter cloacae strain A1137

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CCL06_RS00320 Protein ID WP_025757022.1
Coordinates 58237..58587 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CCL06_RS00315 Protein ID WP_025757021.1
Coordinates 57941..58240 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCL06_RS00285 53316..54275 - 960 WP_025757015.1 DUF523 and DUF1722 domain-containing protein -
CCL06_RS00290 54378..54791 - 414 WP_025757016.1 hydroxyisourate hydrolase -
CCL06_RS00295 54891..55616 - 726 WP_025757017.1 MerR family transcriptional regulator -
CCL06_RS00300 55734..56258 + 525 WP_025757018.1 lipocalin family protein -
CCL06_RS00305 56337..57335 + 999 WP_088244004.1 class I SAM-dependent methyltransferase -
CCL06_RS00310 57474..57911 + 438 WP_025757020.1 acetyltransferase -
CCL06_RS00315 57941..58240 - 300 WP_025757021.1 XRE family transcriptional regulator Antitoxin
CCL06_RS00320 58237..58587 - 351 WP_025757022.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCL06_RS00330 59661..61979 + 2319 WP_025757023.1 alpha-xylosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(42-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13387.50 Da        Isoelectric Point: 9.3790

>T77668 WP_025757022.1 NZ_CP021851:c58587-58237 [Enterobacter cloacae]
MWRVLFGKVFEQWLLAQDEGLQDKVLADLLNLQNYGPHLPRPYADTVKGSRYKHMKELRIQYAGRPIRAFFAFDPVRQAI
VLCADDKSNDKAFYEKMIRIADAEFSLHLTSLGAAK

Download         Length: 351 bp

>T77668 NZ_CP021851:c58587-58237 [Enterobacter cloacae]
ATGTGGAGGGTTCTGTTCGGAAAGGTATTCGAGCAATGGTTGCTTGCACAGGACGAGGGATTACAGGATAAGGTGCTGGC
AGATCTGCTAAATCTGCAAAACTATGGGCCACATCTTCCTCGTCCCTATGCAGATACGGTTAAAGGTTCAAGGTATAAAC
ATATGAAAGAATTACGTATTCAATATGCTGGTCGGCCGATACGTGCTTTCTTCGCATTTGATCCTGTCCGTCAAGCCATT
GTGCTTTGCGCGGATGATAAGAGTAACGACAAAGCCTTTTATGAAAAAATGATTCGTATTGCAGATGCCGAATTTTCTCT
ACATCTGACAAGCCTGGGGGCAGCCAAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11185.03 Da        Isoelectric Point: 8.6182

>AT77668 WP_025757021.1 NZ_CP021851:c58240-57941 [Enterobacter cloacae]
VKTLNEVIASRSPESQQRIKEMAEEMILETGLQLLREELRLSQKNVADLMGVSQPAVTQLEQRGNELKIATLKRYIEAMG
GKLRIDVELPTGKRVAFHI

Download         Length: 300 bp

>AT77668 NZ_CP021851:c58240-57941 [Enterobacter cloacae]
GTGAAAACCTTAAATGAAGTGATTGCGTCACGTTCACCAGAAAGCCAACAACGTATTAAAGAGATGGCAGAGGAAATGAT
CCTCGAAACGGGTCTGCAACTTTTACGTGAAGAGCTCAGGCTTTCGCAAAAAAATGTTGCCGACCTGATGGGGGTGAGCC
AGCCCGCAGTGACACAGTTAGAGCAACGGGGAAATGAACTAAAAATTGCCACGCTTAAGCGCTACATTGAGGCAATGGGT
GGGAAACTCCGTATCGACGTTGAACTTCCCACAGGAAAACGCGTTGCATTTCATATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References