Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 85389..86046 | Replicon | plasmid tig00000516_pilon |
| Accession | NZ_CP021835 | ||
| Organism | Klebsiella pneumoniae strain AR_0120 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | AM367_RS29455 | Protein ID | WP_000270043.1 |
| Coordinates | 85696..86046 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | AM367_RS29450 | Protein ID | WP_000124640.1 |
| Coordinates | 85389..85691 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AM367_RS29400 | 80658..81104 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| AM367_RS29405 | 81101..81619 | + | 519 | WP_000210758.1 | nitrite reductase | - |
| AM367_RS29410 | 81619..81849 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| AM367_RS29415 | 81836..82693 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| AM367_RS29425 | 83002..83982 | + | 981 | WP_012569499.1 | IS5-like element ISKpn26 family transposase | - |
| AM367_RS29435 | 84106..84651 | + | 546 | WP_032413569.1 | thermonuclease family protein | - |
| AM367_RS29440 | 84709..84981 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| AM367_RS29445 | 85069..85362 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| AM367_RS29450 | 85389..85691 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| AM367_RS29455 | 85696..86046 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AM367_RS29460 | 86209..86757 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| AM367_RS29470 | 87098..87292 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| AM367_RS29475 | 87303..87674 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| AM367_RS29480 | 87667..88137 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| AM367_RS29485 | 88152..88487 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| AM367_RS29490 | 88584..89072 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| AM367_RS29495 | 89075..89572 | + | 498 | WP_000062185.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | floR / sul2 / blaKPC-2 / sul1 / qacE / aac(6')-33 / ant(2'')-Ia / blaTEM-1D | - | 1..210045 | 210045 | |
| - | flank | IS/Tn | - | - | 83002..83982 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T77585 WP_000270043.1 NZ_CP021835:c86046-85696 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T77585 NZ_CP021835:c86046-85696 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT77585 WP_000124640.1 NZ_CP021835:c85691-85389 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT77585 NZ_CP021835:c85691-85389 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|