Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1322498..1323032 Replicon plasmid psymB
Accession NZ_CP021828
Organism Sinorhizobium meliloti strain KH35c

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag CDO23_RS34470 Protein ID WP_017268214.1
Coordinates 1322736..1323032 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID H0FXK0
Locus tag CDO23_RS31960 Protein ID WP_003527850.1
Coordinates 1322498..1322746 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO23_RS31925 1317968..1319035 + 1068 WP_010974979.1 ABC transporter substrate-binding protein -
CDO23_RS31930 1319032..1320075 + 1044 WP_010974980.1 iron ABC transporter permease -
CDO23_RS31935 1320072..1320872 + 801 WP_014527655.1 ABC transporter ATP-binding protein -
CDO23_RS31940 1320876..1321670 + 795 WP_014527654.1 methyltransferase domain-containing protein -
CDO23_RS31945 1321754..1321879 - 126 Protein_1181 IS481 family transposase -
CDO23_RS31960 1322498..1322746 + 249 WP_003527850.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CDO23_RS34470 1322736..1323032 + 297 WP_017268214.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDO23_RS34475 1323111..1323371 - 261 Protein_1184 helix-turn-helix domain-containing protein -
CDO23_RS31970 1323945..1324343 + 399 WP_010974988.1 hypothetical protein -
CDO23_RS31975 1324510..1324695 + 186 WP_014527652.1 hypothetical protein -
CDO23_RS31980 1324699..1325145 - 447 WP_014527651.1 DNA-binding protein -
CDO23_RS31985 1325435..1325644 + 210 WP_003527838.1 dodecin family protein -
CDO23_RS31990 1326177..1327556 + 1380 WP_027991363.1 sodium:alanine symporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1624370 1624370
- flank IS/Tn - - 1321754..1321945 191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-93)

Antitoxin

Antitoxin ParD

(3-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11490.20 Da        Isoelectric Point: 10.7543

>T77549 WP_017268214.1 NZ_CP021828:1322736-1323032 [Sinorhizobium meliloti]
MATERPFRLAPAAKADLRKIWRYKARRWSLEQAETYQDQLYTAFEGLAAGTKKGRNVDVRPGYLKYPAGSHIVYFRDRGD
RIDIIRILHGRMDAQRHL

Download         Length: 297 bp

>T77549 NZ_CP021828:1322736-1323032 [Sinorhizobium meliloti]
ATGGCGACTGAACGGCCTTTCCGGCTCGCTCCTGCCGCCAAGGCCGACCTTCGGAAGATATGGCGCTACAAGGCTCGCCG
CTGGTCTCTGGAACAGGCGGAGACCTACCAAGACCAGCTTTATACTGCATTTGAGGGACTGGCGGCAGGGACGAAGAAAG
GCCGCAATGTCGATGTGCGACCGGGTTATCTCAAATACCCGGCAGGATCGCACATCGTCTATTTTCGGGATCGCGGCGAC
CGGATCGACATCATCCGCATCCTGCATGGCCGGATGGATGCCCAACGGCATTTGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8888.73 Da        Isoelectric Point: 4.2176

>AT77549 WP_003527850.1 NZ_CP021828:1322498-1322746 [Sinorhizobium meliloti]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD

Download         Length: 249 bp

>AT77549 NZ_CP021828:1322498-1322746 [Sinorhizobium meliloti]
ATGGCTGCTAGAAGCACATCTATTTCCCTTGGCGATCACTTCGCCGGTTTCATCGACAGCCAGGTGCAAACCGGCCGCTA
CGGCTCCGCCAGCGACGTTGTGCGGGCTGGACTTCGGCTTTTGGAAGAACACGAGGCGAAGGTAAGGGCGCTGGAAGCGG
CTTTGATCGAGGGCGAAGAATCCGGCGAGCCAGAGCCATTCGACAACGAAGCGTTCAAAGCCGAAATGCGCGCCGAATAT
GGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB H0FXK0

References