77547

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 54242..54909 Replicon plasmid psymB
Accession NZ_CP021828
Organism Sinorhizobium meliloti strain KH35c

Toxin (Protein)


Gene name vapC Uniprot ID A0A7X2CQG3
Locus tag CDO23_RS25830 Protein ID WP_014527488.1
Coordinates 54242..54685 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92WE1
Locus tag CDO23_RS25835 Protein ID WP_010975287.1
Coordinates 54682..54909 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO23_RS25810 49699..51891 + 2193 WP_017264375.1 hydantoinase B/oxoprolinase family protein -
CDO23_RS25815 51895..52392 + 498 WP_010975282.1 acetone carboxylase subunit gamma -
CDO23_RS25820 52389..53219 + 831 WP_027988369.1 SDR family oxidoreductase -
CDO23_RS25825 53288..54226 + 939 WP_017264373.1 choline ABC transporter substrate-binding protein -
CDO23_RS25830 54242..54685 - 444 WP_014527488.1 PIN domain-containing protein Toxin
CDO23_RS25835 54682..54909 - 228 WP_010975287.1 hypothetical protein Antitoxin
CDO23_RS25840 55093..55566 - 474 WP_017264371.1 DUF2269 family protein -
CDO23_RS25845 55566..56855 - 1290 WP_014527486.1 SDR family oxidoreductase -
CDO23_RS25855 57224..58516 + 1293 WP_010975290.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
CDO23_RS25860 58634..59515 + 882 WP_010975291.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1624370 1624370


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15592.86 Da        Isoelectric Point: 6.6378

>T77547 WP_014527488.1 NZ_CP021828:c54685-54242 [Sinorhizobium meliloti]
VTFLLDVNVLIALIDPSHIGHDDAHEWFASIGQTAWATCPITENGVIRIVGNPEYPNSPGSPLPAMEIVAKLRSLPGHVF
WPDDVSLVGSSDIIPSKILTSGQVTDTYLLALAKARGGKLATFDRKLSAAAVTKGNSALHLIATNRS

Download         Length: 444 bp

>T77547 NZ_CP021828:c54685-54242 [Sinorhizobium meliloti]
GTGACTTTCCTGCTCGACGTCAATGTGCTGATTGCCTTGATCGATCCGAGCCATATAGGCCATGATGATGCGCACGAATG
GTTCGCGTCGATTGGTCAGACCGCGTGGGCCACCTGCCCAATTACCGAAAATGGTGTCATCCGGATCGTCGGCAATCCCG
AGTATCCCAATTCTCCCGGCTCACCGTTACCCGCGATGGAGATCGTCGCCAAATTGCGGTCGCTCCCCGGTCATGTTTTC
TGGCCGGACGATGTGAGCCTTGTCGGGTCAAGTGATATCATCCCATCGAAAATCCTGACTTCGGGGCAGGTGACTGACAC
CTATCTGCTTGCGCTCGCCAAGGCGCGTGGGGGCAAGCTGGCGACATTCGATCGCAAGCTGTCGGCAGCGGCGGTCACGA
AGGGCAATTCCGCCTTGCACCTGATCGCGACGAATAGGTCGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8174.39 Da        Isoelectric Point: 9.1096

>AT77547 WP_010975287.1 NZ_CP021828:c54909-54682 [Sinorhizobium meliloti]
MRTTLAIDDDVLIAAKAMATQQQRSVGEVISELARRSLRRPRSGGERNGIPLLSPRPDAPPVTLEIVNALRDELA

Download         Length: 228 bp

>AT77547 NZ_CP021828:c54909-54682 [Sinorhizobium meliloti]
ATGAGAACGACCTTGGCTATTGACGACGATGTCCTGATCGCCGCAAAGGCAATGGCGACCCAACAGCAGCGGAGCGTCGG
CGAGGTAATTTCCGAACTGGCGAGGCGTTCTCTGCGCCGGCCGCGCAGCGGCGGCGAGCGTAATGGAATTCCTCTCCTGT
CGCCTCGTCCGGACGCACCGCCCGTGACGCTCGAGATCGTCAACGCCCTGCGTGACGAACTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X2CQG3

Antitoxin

Source ID Structure
AlphaFold DB Q92WE1

References