77531

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 454826..455758 Replicon plasmid psymB
Accession NZ_CP021823
Organism Sinorhizobium meliloti strain KH46

Toxin (Protein)


Gene name - Uniprot ID F7XGP1
Locus tag CDO24_RS20510 Protein ID WP_014530511.1
Coordinates 455204..455758 (+) Length 185 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID F7XGP2
Locus tag CDO24_RS20505 Protein ID WP_014530512.1
Coordinates 454826..455197 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO24_RS20485 450713..451096 + 384 WP_010975573.1 RidA family protein -
CDO24_RS20490 451113..453101 + 1989 WP_014530515.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
CDO24_RS20495 453098..453967 + 870 WP_014530514.1 hydroxymethylglutaryl-CoA lyase -
CDO24_RS20500 453964..454749 + 786 WP_014530513.1 crotonase/enoyl-CoA hydratase family protein -
CDO24_RS20505 454826..455197 + 372 WP_014530512.1 DUF2384 domain-containing protein Antitoxin
CDO24_RS20510 455204..455758 + 555 WP_014530511.1 RES family NAD+ phosphorylase Toxin
CDO24_RS20515 455894..457264 - 1371 WP_015008367.1 FAD-binding oxidoreductase -
CDO24_RS20520 457376..458482 - 1107 WP_013850797.1 sulfate/molybdate ABC transporter ATP-binding protein -
CDO24_RS20525 458498..459373 - 876 WP_013850796.1 sulfate ABC transporter permease subunit CysW -
CDO24_RS20530 459363..460229 - 867 WP_015008365.1 sulfate ABC transporter permease subunit CysT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1683883 1683883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(23-177)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20449.31 Da        Isoelectric Point: 6.4901

>T77531 WP_014530511.1 NZ_CP021823:455204-455758 [Sinorhizobium meliloti]
MRKHIPPASRPDSEPTSPVEPITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGMPAIYAARELSTAWAEYNQGFVQHPAL
IVQLELRGARLADLTDASVLLELGVDEAIHRCEWRDALDKGAVPETHRLQSELLARDYHGVIYPSFMSPGGTCVALWRWN
GAEEPRLDVIDPDGRLPKSPASWV

Download         Length: 555 bp

>T77531 NZ_CP021823:455204-455758 [Sinorhizobium meliloti]
ATGAGGAAACACATTCCGCCCGCATCGCGACCCGATTCGGAACCGACGTCGCCGGTCGAGCCGATAACGCTCTGGCGCGC
CTTCGTTCCGCGCTGGGCACATATGCCGCTATCCGGCGCGGGTGCCGCTCGCTTCGGTGGCCGCTGGAACCCGATCGGCA
TGCCTGCGATTTATGCTGCGCGCGAGCTTTCCACTGCCTGGGCTGAATATAATCAGGGTTTCGTCCAGCATCCGGCGCTC
ATCGTGCAGCTCGAGTTGCGCGGGGCGAGGCTCGCGGACCTCACGGATGCCAGCGTTCTTCTGGAGCTTGGTGTGGATGA
GGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAAGGCGCGGTGCCGGAGACCCACAGGCTGCAGTCGGAGCTTC
TGGCGCGCGACTATCACGGGGTGATCTATCCATCCTTCATGTCGCCCGGCGGCACCTGCGTCGCGCTCTGGCGCTGGAAC
GGTGCGGAAGAACCGCGTCTCGACGTCATCGATCCCGATGGCCGGCTGCCGAAATCGCCCGCCTCATGGGTTTGA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13117.25 Da        Isoelectric Point: 9.6233

>AT77531 WP_014530512.1 NZ_CP021823:454826-455197 [Sinorhizobium meliloti]
MMAVDFQIAAARFGDDHSPFLSARLVADWLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA

Download         Length: 372 bp

>AT77531 NZ_CP021823:454826-455197 [Sinorhizobium meliloti]
ATGATGGCCGTTGATTTCCAGATAGCTGCAGCCCGTTTCGGGGACGATCATTCCCCGTTTCTCTCGGCCCGCCTTGTCGC
CGACTGGTTGGGCGTCACGCTCGCCGAACTCGCCAAGCTGATCGGTGTCGCCCGCAATACGCTGACGGCGAAATCCGGCG
CCCGGAAGGTCGACAGCGCCTTGAGCAAGGTCGTCCGCATCCTCGCCATGGCTTCCGAAATGGCGGGCGACGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATCCCCGGCTGGGCCGGCAAGACGGCGTTCGATCTGGTCGGCGAGGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGTGCCGGCGTCTACGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A222K2B4

Antitoxin

Source ID Structure
AlphaFold DB A0A222K374

References