Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1027346..1027880 Replicon plasmid psymB
Accession NZ_CP021806
Organism Sinorhizobium meliloti strain T073

Toxin (Protein)


Gene name parE Uniprot ID Q92X99
Locus tag CDO28_RS30905 Protein ID WP_010974986.1
Coordinates 1027584..1027880 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID H0FXK0
Locus tag CDO28_RS30900 Protein ID WP_003527850.1
Coordinates 1027346..1027594 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO28_RS30865 1022798..1023883 + 1086 WP_014530873.1 ABC transporter substrate-binding protein -
CDO28_RS30870 1023880..1024923 + 1044 WP_010974980.1 iron ABC transporter permease -
CDO28_RS30875 1024920..1025720 + 801 WP_010974981.1 ABC transporter ATP-binding protein -
CDO28_RS30880 1025724..1026518 + 795 WP_013850206.1 methyltransferase domain-containing protein -
CDO28_RS30885 1026602..1026727 - 126 Protein_913 IS481 family transposase -
CDO28_RS30895 1027083..1027238 + 156 WP_010974985.1 hypothetical protein -
CDO28_RS30900 1027346..1027594 + 249 WP_003527850.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CDO28_RS30905 1027584..1027880 + 297 WP_010974986.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDO28_RS30910 1027961..1028221 - 261 Protein_917 helix-turn-helix domain containing protein -
CDO28_RS30915 1028802..1029200 + 399 WP_010974988.1 hypothetical protein -
CDO28_RS30920 1029367..1029552 + 186 WP_010974989.1 hypothetical protein -
CDO28_RS30925 1029556..1030002 - 447 WP_192925882.1 DNA-binding protein -
CDO28_RS30930 1030292..1030501 + 210 WP_003527838.1 dodecin family protein -
CDO28_RS30935 1031035..1032438 + 1404 WP_026029937.1 sodium:alanine symporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1646425 1646425
- flank IS/Tn - - 1026602..1026793 191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-91)

Antitoxin

Antitoxin ParD

(3-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11473.15 Da        Isoelectric Point: 10.6593

>T77476 WP_010974986.1 NZ_CP021806:1027584-1027880 [Sinorhizobium meliloti]
MATERPFRLAPTAKADLRKIWRYTARRWSLEQAETYQDQLYTAFEGLAVGTKKGRNVDVRPGYLKYPAGAHIVYFRDRGD
RIDIIRILHGRVDAQRHL

Download         Length: 297 bp

>T77476 NZ_CP021806:1027584-1027880 [Sinorhizobium meliloti]
ATGGCGACTGAACGGCCTTTCCGGCTCGCTCCTACCGCCAAGGCCGACCTTCGGAAGATATGGCGCTACACGGCTCGCCG
CTGGTCTCTGGAACAGGCGGAGACCTACCAAGACCAGCTTTATACTGCATTTGAGGGACTGGCCGTAGGGACGAAGAAAG
GCCGCAATGTCGATGTGCGGCCGGGTTATCTCAAATACCCGGCAGGAGCGCACATCGTCTATTTTCGGGATCGCGGCGAC
CGGATCGACATCATCCGCATCCTGCATGGCCGTGTGGACGCCCAACGGCATTTGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8888.73 Da        Isoelectric Point: 4.2176

>AT77476 WP_003527850.1 NZ_CP021806:1027346-1027594 [Sinorhizobium meliloti]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD

Download         Length: 249 bp

>AT77476 NZ_CP021806:1027346-1027594 [Sinorhizobium meliloti]
ATGGCTGCTAGAAGCACATCTATTTCCCTTGGCGATCACTTCGCCGGTTTCATCGACAGCCAGGTGCAAACCGGCCGCTA
CGGCTCCGCCAGCGACGTTGTGCGGGCTGGACTTCGGCTTTTGGAAGAACACGAGGCGAAGGTAAGGGCGCTGGAAGCGG
CCTTGATCGAGGGCGAAGAATCCGGCGAGCCAGAGCCATTCGACAACGAAGCGTTCAAAGCCGAAATGCGCGCCGAATAT
GGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92X99

Antitoxin

Source ID Structure
AlphaFold DB H0FXK0

References