77444

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 140055..140589 Replicon plasmid psymB
Accession NZ_CP021799
Organism Sinorhizobium meliloti strain USDA1106

Toxin (Protein)


Gene name parE Uniprot ID Q92X99
Locus tag CDO30_RS25780 Protein ID WP_010974986.1
Coordinates 140293..140589 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID H0FXK0
Locus tag CDO30_RS25775 Protein ID WP_003527850.1
Coordinates 140055..140303 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO30_RS25740 135245..136288 + 1044 WP_010974980.1 iron ABC transporter permease -
CDO30_RS25745 136285..137085 + 801 WP_010974981.1 ABC transporter ATP-binding protein -
CDO30_RS25750 137089..137868 + 780 WP_010974982.1 methyltransferase domain-containing protein -
CDO30_RS25755 137960..139156 + 1197 WP_010974983.1 IS256-like element ISRm5 family transposase -
CDO30_RS25760 139315..139440 - 126 Protein_120 IS481 family transposase -
CDO30_RS25770 139796..139951 + 156 WP_010974985.1 hypothetical protein -
CDO30_RS25775 140055..140303 + 249 WP_003527850.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CDO30_RS25780 140293..140589 + 297 WP_010974986.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDO30_RS25785 140670..140930 - 261 Protein_124 helix-turn-helix domain containing protein -
CDO30_RS25790 141509..141907 + 399 WP_010974988.1 hypothetical protein -
CDO30_RS25795 142074..142259 + 186 WP_010974989.1 hypothetical protein -
CDO30_RS25800 142263..142709 - 447 WP_041170054.1 DNA-binding protein -
CDO30_RS25805 142999..143208 + 210 WP_003527838.1 dodecin family protein -
CDO30_RS25810 143742..145145 + 1404 WP_010974991.1 sodium:alanine symporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1680729 1680729


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-91)

Antitoxin

Antitoxin ParD

(3-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11473.15 Da        Isoelectric Point: 10.6593

>T77444 WP_010974986.1 NZ_CP021799:140293-140589 [Sinorhizobium meliloti]
MATERPFRLAPTAKADLRKIWRYTARRWSLEQAETYQDQLYTAFEGLAVGTKKGRNVDVRPGYLKYPAGAHIVYFRDRGD
RIDIIRILHGRVDAQRHL

Download         Length: 297 bp

>T77444 NZ_CP021799:140293-140589 [Sinorhizobium meliloti]
ATGGCGACTGAACGGCCTTTCCGGCTCGCTCCTACCGCCAAGGCCGACCTTCGGAAGATATGGCGCTACACGGCTCGCCG
CTGGTCTCTGGAACAGGCGGAGACCTACCAAGACCAGCTTTATACTGCATTTGAGGGACTGGCCGTAGGGACGAAGAAAG
GCCGCAATGTCGATGTGCGGCCGGGTTATCTCAAATACCCGGCAGGAGCGCACATCGTCTATTTTCGGGATCGCGGCGAC
CGGATCGACATCATCCGCATCCTGCATGGCCGTGTGGACGCCCAACGGCATTTGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8888.73 Da        Isoelectric Point: 4.2176

>AT77444 WP_003527850.1 NZ_CP021799:140055-140303 [Sinorhizobium meliloti]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD

Download         Length: 249 bp

>AT77444 NZ_CP021799:140055-140303 [Sinorhizobium meliloti]
ATGGCTGCTAGAAGCACATCTATTTCCCTTGGCGATCACTTCGCCGGTTTCATCGACAGCCAGGTGCAAACCGGCCGCTA
CGGCTCCGCCAGCGACGTTGTGCGGGCTGGACTTCGGCTTTTGGAAGAACACGAGGCGAAGGTAAGGGCGCTGGAAGCGG
CTTTGATCGAGGGCGAAGAATCCGGCGAGCCAGAGCCATTCGACAACGAAGCGTTCAAAGCCGAAATGCGCGCCGAATAT
GGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92X99

Antitoxin

Source ID Structure
AlphaFold DB H0FXK0

References