Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 921023..921537 Replicon chromosome
Accession NZ_CP021790
Organism Limosilactobacillus fermentum strain LAC FRN-92

Toxin (Protein)


Gene name yoeB Uniprot ID D0DT30
Locus tag CDH44_RS04795 Protein ID WP_004562989.1
Coordinates 921274..921537 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID D0DT29
Locus tag CDH44_RS04790 Protein ID WP_004562988.1
Coordinates 921023..921277 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDH44_RS04775 916414..917253 + 840 WP_049184706.1 PRD domain-containing protein -
CDH44_RS04780 917361..919340 + 1980 WP_087908097.1 beta-glucoside-specific PTS transporter subunit IIABC -
CDH44_RS04785 919386..920861 + 1476 WP_087908098.1 family 1 glycosylhydrolase -
CDH44_RS04790 921023..921277 + 255 WP_004562988.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CDH44_RS04795 921274..921537 + 264 WP_004562989.1 Txe/YoeB family addiction module toxin Toxin
CDH44_RS04800 921707..922828 - 1122 WP_087908099.1 PTS sugar transporter subunit IIC -
CDH44_RS04805 923243..923830 - 588 Protein_919 IS30 family transposase -
CDH44_RS04815 923931..924284 + 354 Protein_920 transposase -
CDH44_RS04820 924339..926018 - 1680 WP_087908100.1 D-lactate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-55)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10304.04 Da        Isoelectric Point: 10.4974

>T77414 WP_004562989.1 NZ_CP021790:921274-921537 [Limosilactobacillus fermentum]
MSYAIKLKRSANKDLKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVPPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSRYE

Download         Length: 264 bp

>T77414 NZ_CP021790:921274-921537 [Limosilactobacillus fermentum]
ATGAGTTACGCGATCAAACTCAAGCGGAGCGCTAATAAAGATCTCAAGAAAATTAAGGGGTCATATTTAGAAAAGAGCTT
CTTGCAAATAATTGAGCAGCTCCGTAAAGACCCCTTGGCACCCAACCAAGGCTTTGAAAAATTAGTACCGCCAATTAAGG
GCTTTTACTCCCGTCGGATTAACATTCAGCACCGACTCGTCTATAAGGTTGATCAAGACACGCAAACTGTGATCATCTAT
TCTGCGTGGTCACGTTACGAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9730.97 Da        Isoelectric Point: 4.3108

>AT77414 WP_004562988.1 NZ_CP021790:921023-921277 [Limosilactobacillus fermentum]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTKADEKSVVVIGEDDWKAIQETLFLVNHGVDKQINERENEPLDDFDDV
WGQL

Download         Length: 255 bp

>AT77414 NZ_CP021790:921023-921277 [Limosilactobacillus fermentum]
ATGGACCAAATTGTAACCCCAACGCAAGCACGGAAAGATTTATTCAAAATAATCAAAAGGATCAATGAAAATAATGAGCC
GGTTGTGATTAAGCCGACCAAGGCGGATGAAAAGAGCGTTGTCGTCATTGGTGAAGATGACTGGAAAGCAATCCAAGAAA
CGTTATTTTTGGTTAATCACGGTGTTGACAAGCAAATTAATGAACGGGAAAACGAGCCGCTCGACGACTTTGATGATGTT
TGGGGTCAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z0CGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A843QZ89

References