Detailed information of TA system TA077413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4807105..4807694
• Replicon: chromosome
• Accession: NZ_CP021789
• Organism: Xanthomonas oryzae pv. oryzae strain PXO61

Toxin (Protein)

• Gene name: graT
• Uniprot ID: G7TIR7
• Locus tag: CDO11_RS23860
• Protein ID: WP_012443754.1
• Coordinates: 4807413..4807694 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CDO11_RS23855
• Protein ID: WP_011260746.1
• Coordinates: 4807105..4807395 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDO11_RS23815 (CDO11_23455)	4802258..4802866	-	609	WP_011409746.1	DUF4123 domain-containing protein	-
CDO11_RS23820 (CDO11_23460)	4802869..4803282	-	414	WP_228383576.1	PAAR domain-containing protein	-
CDO11_RS23825 (CDO11_23465)	4803419..4803745	-	327	WP_228329596.1	hypothetical protein	-
CDO11_RS23835 (CDO11_23475)	4804000..4804332	+	333	WP_011260743.1	hypothetical protein	-
CDO11_RS25890	4804492..4804679	+	188	Protein_4322	hypothetical protein	-
CDO11_RS23845 (CDO11_23485)	4804782..4806176	-	1395	WP_027703652.1	type III secretion system effector XopQ	-
CDO11_RS23855 (CDO11_23495)	4807105..4807395	-	291	WP_011260746.1	HigA family addiction module antitoxin	Antitoxin
CDO11_RS23860 (CDO11_23500)	4807413..4807694	-	282	WP_012443754.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CDO11_RS23865 (CDO11_23505)	4807789..4810041	-	2253	WP_069960050.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11066.83 Da
• Isoelectric Point: 10.5318

>T77413 WP_012443754.1 NZ_CP021789:c4807694-4807413 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Nucleotide

• Length: 282 bp

>T77413 NZ_CP021789:c4807694-4807413 [Xanthomonas oryzae pv. oryzae]
GTGATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCACATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGGCGCGGCCAGTACAGCATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10420.07 Da
• Isoelectric Point: 7.2040

>AT77413 WP_011260746.1 NZ_CP021789:c4807395-4807105 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT77413 NZ_CP021789:c4807395-4807105 [Xanthomonas oryzae pv. oryzae]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAATGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0K0GFW5