77394

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2181435..2182092 Replicon chromosome
Accession NZ_CP021776
Organism Enterobacter cloacae complex sp. strain AR_0053

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AM432_RS10825 Protein ID WP_032609983.1
Coordinates 2181435..2181734 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AM432_RS10830 Protein ID WP_032609984.1
Coordinates 2181745..2182092 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM432_RS10815 (AM432_10810) 2177812..2180004 + 2193 WP_032609980.1 type I secretion system permease/ATPase -
AM432_RS10820 (AM432_10815) 2179985..2181184 + 1200 WP_032609982.1 HlyD family efflux transporter periplasmic adaptor subunit -
AM432_RS10825 (AM432_10820) 2181435..2181734 + 300 WP_032609983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM432_RS10830 (AM432_10825) 2181745..2182092 + 348 WP_032609984.1 HigA family addiction module antitoxin Antitoxin
AM432_RS10835 (AM432_10830) 2182168..2183349 - 1182 WP_023314694.1 PLP-dependent aminotransferase family protein -
AM432_RS10840 (AM432_10835) 2183370..2184257 - 888 WP_022651703.1 LysR family transcriptional regulator -
AM432_RS10845 (AM432_10840) 2184355..2184957 + 603 WP_022651704.1 short chain dehydrogenase -
AM432_RS10850 (AM432_10845) 2184954..2185685 - 732 WP_022651705.1 class I SAM-dependent methyltransferase -
AM432_RS10855 (AM432_10850) 2185760..2186758 - 999 WP_022651706.1 transketolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-103)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11610.24 Da        Isoelectric Point: 9.6776

>T77394 WP_032609983.1 NZ_CP021776:2181435-2181734 [Enterobacter cloacae complex sp.]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNIYEALSPTLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T77394 NZ_CP021776:2181435-2181734 [Enterobacter cloacae complex sp.]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TATATGAAGCATTGAGTCCTACGTTGAAGGGATACTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13094.06 Da        Isoelectric Point: 9.5932

>AT77394 WP_032609984.1 NZ_CP021776:2181745-2182092 [Enterobacter cloacae complex sp.]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEVLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWETQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT77394 NZ_CP021776:2181745-2182092 [Enterobacter cloacae complex sp.]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGGTGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAACGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCGGACGTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References