Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5432926..5433607 Replicon chromosome
Accession NZ_CP021775
Organism Pseudomonas aeruginosa strain Pa58

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CDL16_RS26430 Protein ID WP_015503432.1
Coordinates 5433242..5433607 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CDL16_RS26425 Protein ID WP_004364117.1
Coordinates 5432926..5433249 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDL16_RS26395 5428702..5429279 + 578 Protein_5103 plasmid pRiA4b ORF-3 family protein -
CDL16_RS26410 5431300..5431854 - 555 WP_074197746.1 tyrosine-type recombinase/integrase -
CDL16_RS26415 5432029..5432304 - 276 WP_004364115.1 hypothetical protein -
CDL16_RS26420 5432304..5432636 - 333 WP_016561578.1 hypothetical protein -
CDL16_RS35085 5432691..5432810 + 120 Protein_5108 IS5/IS1182 family transposase -
CDL16_RS26425 5432926..5433249 - 324 WP_004364117.1 XRE family transcriptional regulator Antitoxin
CDL16_RS26430 5433242..5433607 - 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDL16_RS26435 5433871..5434110 - 240 WP_044069615.1 hypothetical protein -
CDL16_RS26440 5434317..5434589 + 273 WP_004364121.1 hypothetical protein -
CDL16_RS26445 5434620..5435045 - 426 WP_003116492.1 VOC family protein -
CDL16_RS26450 5435146..5436030 + 885 WP_004364122.1 LysR family transcriptional regulator -
CDL16_RS26455 5436003..5436956 - 954 WP_003085661.1 LysR family transcriptional regulator -
CDL16_RS26460 5437177..5437611 + 435 WP_003158601.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5399483..5435045 35562


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T77380 WP_015503432.1 NZ_CP021775:c5433607-5433242 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

>T77380 NZ_CP021775:c5433607-5433242 [Pseudomonas aeruginosa]
GTGGCGTGGGATATCGAGTACACCGACGAGTTCGGTGATTGGTGGGGTTCTCTGTCCGAGGATGAGCAGGAGTCGCTAGC
TGTGACGGTTCGCTTGCTTGAGGAGCGGGGGCCATCCTTGGGGCACCCCCACAGCAGCGGCATCAATGGCTCCCGCCCTG
GCCATATGAGAGAGCTACGGACTCAACACGGCGGGCGACCTTTCCGAACGCTTTACGCGTTTGACCCCAGACGCTCCGCG
ATACTGCCGATCGGTGGCGACAAGACTGGCGATGATCGTTGGTACGAATTGAACGTGCCCATTGCCGACCGCCTCCATGA
CGAACACTTGCACCAGCTCCGTGAGGAGGGACTGATCGATGGCTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT77380 WP_004364117.1 NZ_CP021775:c5433249-5432926 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GHLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT77380 NZ_CP021775:c5433249-5432926 [Pseudomonas aeruginosa]
ATGGCTAAGAAATTCTCCGACCTTCGGGCGCAAATGTCGCCTGAGGCACAGGCCCGCGTCGAGGCCAAGGCCCAGGAACT
GTTGGCTGAAATGCCCCTGAATGAGTTGCGCCAGGCTAGAGGCTTGTCGCAGAAGATGCTGTCTGAAGTGCTGCAGGTGC
AGCAGCCGGCAATTGCCAAGATGGAGCGGCGTACGGATATGTACATCTCCACCTTGCGCAGCCACATCGAAGCCATGGGC
GGCCATCTGGAAGTGATTGCACGCTTCCCGGATGGCGCGGTGAAAATCAGCAACTTCGCTGATATCGAAGAGGCGGGCGC
CTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References