Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 14162..14675 Replicon chromosome
Accession NZ_CP021773
Organism Streptococcus agalactiae strain B105

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag CCZ24_RS00090 Protein ID WP_000481712.1
Coordinates 14421..14675 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag CCZ24_RS00085 Protein ID WP_000387490.1
Coordinates 14162..14428 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ24_RS00050 9816..10193 + 378 WP_000287186.1 hypothetical protein -
CCZ24_RS00055 10177..10476 + 300 WP_000737133.1 helix-turn-helix domain-containing protein -
CCZ24_RS00060 10673..12022 + 1350 WP_000491712.1 AAA family ATPase -
CCZ24_RS00065 12025..12594 + 570 WP_000010056.1 hypothetical protein -
CCZ24_RS00070 12729..13001 + 273 WP_000017154.1 hypothetical protein -
CCZ24_RS00075 13054..13536 + 483 WP_000383283.1 antirestriction protein ArdA -
CCZ24_RS00080 13544..14017 + 474 WP_000560386.1 hypothetical protein -
CCZ24_RS00085 14162..14428 + 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CCZ24_RS00090 14421..14675 + 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
CCZ24_RS00095 14728..15681 + 954 WP_000565540.1 conjugal transfer protein -
CCZ24_RS00100 15702..15968 + 267 WP_001055037.1 hypothetical protein -
CCZ24_RS00105 15979..16389 + 411 WP_000390747.1 conjugal transfer protein -
CCZ24_RS00110 16410..18911 + 2502 WP_000239414.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3112..26555 23443


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T77361 WP_000481712.1 NZ_CP021773:14421-14675 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T77361 NZ_CP021773:14421-14675 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT77361 WP_000387490.1 NZ_CP021773:14162-14428 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT77361 NZ_CP021773:14162-14428 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References