77359

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1203647..1204160 Replicon chromosome
Accession NZ_CP021772
Organism Streptococcus agalactiae strain B111

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag CDH81_RS06010 Protein ID WP_000481712.1
Coordinates 1203647..1203901 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag CDH81_RS06015 Protein ID WP_000387490.1
Coordinates 1203894..1204160 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDH81_RS05990 1199418..1201919 - 2502 WP_162632188.1 ATP-binding protein -
CDH81_RS05995 1201940..1202350 - 411 WP_000390749.1 conjugal transfer protein -
CDH81_RS06000 1202354..1202620 - 267 WP_001055037.1 hypothetical protein -
CDH81_RS06005 1202641..1203594 - 954 WP_017827997.1 conjugal transfer protein -
CDH81_RS06010 1203647..1203901 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
CDH81_RS06015 1203894..1204160 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CDH81_RS06020 1204305..1204778 - 474 WP_000560386.1 hypothetical protein -
CDH81_RS06025 1204786..1205268 - 483 WP_112494018.1 antirestriction protein ArdA -
CDH81_RS06030 1205320..1205592 - 273 WP_025195805.1 hypothetical protein -
CDH81_RS06035 1205719..1206171 - 453 WP_025195806.1 transcriptional regulator -
CDH81_RS06040 1206155..1206532 - 378 WP_000287184.1 hypothetical protein -
CDH81_RS06045 1206548..1207780 - 1233 WP_000338840.1 replication initiation factor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T77359 WP_000481712.1 NZ_CP021772:c1203901-1203647 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T77359 NZ_CP021772:c1203901-1203647 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT77359 WP_000387490.1 NZ_CP021772:c1204160-1203894 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT77359 NZ_CP021772:c1204160-1203894 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References