Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3877869..3878415 Replicon chromosome
Accession NZ_CP021768
Organism Stenotrophomonas sp. WZN-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CCR98_RS18085 Protein ID WP_087923681.1
Coordinates 3878179..3878415 (-) Length 79 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CCR98_RS18080 Protein ID WP_006471116.1
Coordinates 3877869..3878168 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCR98_RS18060 3873317..3874501 + 1185 WP_087924231.1 pyridoxal phosphate-dependent aminotransferase -
CCR98_RS18065 3874611..3876707 - 2097 WP_087923678.1 prolyl oligopeptidase family protein -
CCR98_RS18070 3876777..3877100 - 324 WP_087923679.1 hypothetical protein -
CCR98_RS18075 3877229..3877828 + 600 WP_087923680.1 lipocalin family protein -
CCR98_RS18080 3877869..3878168 - 300 WP_006471116.1 HigA family addiction module antidote protein Antitoxin
CCR98_RS18085 3878179..3878415 - 237 WP_087923681.1 plasmid maintenance system killer protein Toxin
CCR98_RS18090 3878624..3879313 - 690 WP_087923682.1 ABC transporter permease -
CCR98_RS18095 3879310..3880317 - 1008 WP_087923683.1 methionine ABC transporter ATP-binding protein -
CCR98_RS18100 3880480..3881376 - 897 WP_014038546.1 DMT family transporter -
CCR98_RS18105 3881486..3881968 + 483 WP_014038547.1 YajQ family cyclic di-GMP-binding protein -
CCR98_RS18110 3882070..3882636 + 567 WP_087923684.1 DUF1415 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-78)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 9194.59 Da        Isoelectric Point: 9.4804

>T77353 WP_087923681.1 NZ_CP021768:c3878415-3878179 [Stenotrophomonas sp. WZN-1]
MIRSFRCKQTRALFEGTCPRAWRQIRRVAERKLQLLDSAQTLAFLRSPPDSLRINDQWRLCFIWTDGGADAVEIVDYH

Download         Length: 237 bp

>T77353 NZ_CP021768:c3878415-3878179 [Stenotrophomonas sp. WZN-1]
ATGATCCGTTCATTCCGCTGCAAGCAGACCCGCGCCCTGTTTGAAGGAACCTGCCCACGCGCCTGGCGCCAGATCCGGCG
AGTGGCGGAACGCAAACTGCAACTGCTCGACTCGGCACAGACGTTGGCCTTCCTCCGCAGCCCGCCCGACAGCCTTCGCA
TCAACGATCAATGGCGGCTCTGCTTTATCTGGACCGACGGCGGCGCCGATGCCGTGGAAATTGTTGACTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10869.59 Da        Isoelectric Point: 11.3450

>AT77353 WP_006471116.1 NZ_CP021768:c3878168-3877869 [Stenotrophomonas sp. WZN-1]
MKRPHNGMRAIHPGEILREEFLLPLALSVNALAKALDVPATRLHAIVHGQRSISADTAARLARHFGGDAASWLAMQAAYD
LKTLPTRSEIERRVQPRAA

Download         Length: 300 bp

>AT77353 NZ_CP021768:c3878168-3877869 [Stenotrophomonas sp. WZN-1]
ATGAAGCGTCCCCATAACGGCATGCGCGCCATCCATCCTGGCGAGATCCTGCGCGAAGAGTTCCTGCTGCCCTTGGCGCT
GAGCGTGAATGCGCTGGCAAAGGCCCTGGATGTGCCCGCAACGCGACTGCACGCCATCGTGCACGGCCAACGCAGCATTT
CGGCGGACACTGCAGCGCGGCTGGCGCGGCATTTTGGTGGGGATGCCGCGTCCTGGCTCGCGATGCAGGCGGCCTACGAT
CTCAAGACATTGCCAACGCGCAGCGAAATCGAACGCCGGGTGCAGCCACGCGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References