Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 103989..104626 Replicon plasmid unnamed
Accession NZ_CP021767
Organism Ralstonia solanacearum strain RS 489

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CDC59_RS16385 Protein ID WP_097909322.1
Coordinates 103989..104318 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CDC59_RS16390 Protein ID WP_003262799.1
Coordinates 104315..104626 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDC59_RS16370 99694..100857 - 1164 WP_097909321.1 2-methylcitrate synthase -
CDC59_RS16375 100896..101792 - 897 WP_013207461.1 methylisocitrate lyase -
CDC59_RS16380 101986..103938 + 1953 WP_043944394.1 propionate catabolism operon regulatory protein PrpR -
CDC59_RS16385 103989..104318 + 330 WP_097909322.1 toxin Toxin
CDC59_RS16390 104315..104626 + 312 WP_003262799.1 transcriptional regulator Antitoxin
CDC59_RS16395 104858..105166 - 309 WP_003262797.1 type II toxin-antitoxin system YafQ family toxin -
CDC59_RS16400 105111..105422 - 312 WP_042591203.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
CDC59_RS16405 106009..106842 - 834 WP_097909727.1 DUF2242 domain-containing protein -
CDC59_RS16410 107124..107546 + 423 WP_064046042.1 hypothetical protein -
CDC59_RS16420 107690..108430 - 741 WP_064046043.1 metallophosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgG / fliM / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..1999547 1999547
- flank IS/Tn - - 108776..109762 986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-91)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12573.12 Da        Isoelectric Point: 5.7762

>T77348 WP_097909322.1 NZ_CP021767:103989-104318 [Ralstonia solanacearum]
MDATPIELPREHYLSDDEYSALQQELLAQPDAGDVIKGTGGLRKLRFSDKRRGKGQRGGLRVIYYHWDGGSQFWMFVVYD
KDEAIDLSSDERKVLARLLEQEVKARSER

Download         Length: 330 bp

>T77348 NZ_CP021767:103989-104318 [Ralstonia solanacearum]
ATGGATGCTACCCCCATTGAGTTGCCGCGGGAGCACTATCTCTCGGACGACGAGTACAGCGCCCTTCAACAGGAACTGCT
CGCCCAGCCGGACGCCGGCGATGTCATCAAGGGGACAGGTGGTCTACGCAAGCTGCGGTTTTCGGACAAGCGGCGCGGCA
AAGGTCAGCGCGGCGGTCTGCGCGTCATCTACTACCACTGGGATGGAGGCAGCCAATTCTGGATGTTTGTCGTCTACGAC
AAGGATGAGGCGATCGATCTTTCCAGTGACGAGCGCAAAGTGCTGGCACGGTTGTTGGAGCAGGAAGTCAAGGCAAGGAG
TGAGCGATGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11620.59 Da        Isoelectric Point: 10.3969

>AT77348 WP_003262799.1 NZ_CP021767:104315-104626 [Ralstonia solanacearum]
MKRNLFAELKEGMDALAAEREGKMTLRKVEVRVLQPIDVTAEEIKAVRAAAHASQAVMARRLRVNVRTYQNWEQGTAKPN
TQAAVLIKLVEKHPETLQMLEAL

Download         Length: 312 bp

>AT77348 NZ_CP021767:104315-104626 [Ralstonia solanacearum]
ATGAAACGGAACCTGTTTGCTGAATTGAAGGAGGGGATGGATGCGCTTGCCGCAGAGCGCGAAGGAAAGATGACCCTCCG
CAAGGTCGAGGTCCGCGTGCTCCAGCCGATTGATGTCACCGCCGAGGAAATCAAGGCCGTTCGCGCAGCGGCACATGCCT
CACAGGCTGTCATGGCGCGTCGGCTGCGCGTCAATGTGCGCACCTACCAGAACTGGGAACAAGGCACCGCCAAACCGAAC
ACCCAGGCGGCCGTGTTGATCAAGCTCGTCGAGAAGCATCCGGAAACGTTGCAGATGCTGGAAGCGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References