Detailed information of TA system TA077281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 6133663..6134195
• Replicon: chromosome
• Accession: NZ_CP021748
• Organism: Streptomyces alboflavus strain MDJK44

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: SMD44_RS27575
• Protein ID: WP_087885723.1
• Coordinates: 6133941..6134195 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: SMD44_RS27570
• Protein ID: WP_087885722.1
• Coordinates: 6133663..6133944 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMD44_RS27550	6129533..6130528	+	996	WP_078619562.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
SMD44_RS27555	6130604..6131356	+	753	WP_087885721.1	ROK family protein	-
SMD44_RS27560	6131463..6131948	-	486	WP_030358064.1	hypothetical protein	-
SMD44_RS27565	6132384..6133472	+	1089	WP_030358065.1	redox-regulated ATPase YchF	-
SMD44_RS27570	6133663..6133944	+	282	WP_087885722.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SMD44_RS27575	6133941..6134195	+	255	WP_087885723.1	Txe/YoeB family addiction module toxin	Toxin
SMD44_RS27585	6135438..6138119	+	2682	WP_087885725.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-65)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10126.62 Da
• Isoelectric Point: 8.4461

>T77281 WP_087885723.1 NZ_CP021748:6133941-6134195 [Streptomyces alboflavus]
VRLVFEDQGWEDYTSWLKNDRKMLARINKLIEDVKRDPFTGIGKPEPLRYHLPGAWSRRIDDEHRLVYLVTDKEIVILAA
RYHY

Nucleotide

• Length: 255 bp

>T77281 NZ_CP021748:6133941-6134195 [Streptomyces alboflavus]
GTGAGGCTTGTCTTCGAGGATCAGGGCTGGGAGGACTACACGTCCTGGCTCAAGAACGACCGCAAGATGCTCGCTCGGAT
CAACAAGCTCATTGAGGACGTCAAGCGGGACCCCTTCACGGGGATCGGCAAGCCCGAGCCACTCAGGTACCACTTGCCAG
GGGCTTGGTCGAGGCGAATCGACGATGAGCACCGTCTCGTCTACCTGGTCACCGACAAAGAGATCGTCATCCTTGCCGCT
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10017.31 Da
• Isoelectric Point: 5.1133

>AT77281 WP_087885722.1 NZ_CP021748:6133663-6133944 [Streptomyces alboflavus]
MSITASEARKALFPLIKKVNDDHVAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALSNINVSEREL
IDPDAADPAEGAA

Nucleotide

• Length: 282 bp

>AT77281 NZ_CP021748:6133663-6133944 [Streptomyces alboflavus]
ATGTCGATAACTGCGAGTGAAGCCCGCAAGGCTCTCTTTCCGCTGATCAAGAAGGTCAACGACGATCACGTGGCCATCGA
GATCGTGTCCAAGCATGGCAACGCCGTACTTGTCTCGGCGGAGGACTATGCGGCGCTGCGCGAGGGCTCGTACCTGCTGC
GCTCGCCTGCGAACGCACGGCGCCTGCTCAAGGCATACGAGAATGCTCTGAGCAACATCAACGTCTCGGAGCGCGAGCTG
ATTGATCCCGATGCGGCGGATCCTGCTGAGGGTGCTGCGTGA