Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1117482..1118175 Replicon chromosome
Accession NZ_CP021736
Organism Escherichia coli strain AR_0150

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag AM397_RS05500 Protein ID WP_000415584.1
Coordinates 1117879..1118175 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag AM397_RS05495 Protein ID WP_000650107.1
Coordinates 1117482..1117877 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM397_RS05485 1113346..1115604 - 2259 WP_032329482.1 DNA topoisomerase IV subunit A -
AM397_RS05490 1115742..1117349 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
AM397_RS05495 1117482..1117877 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
AM397_RS05500 1117879..1118175 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
AM397_RS05505 1118380..1118862 - 483 WP_000183505.1 transcriptional regulator -
AM397_RS05510 1118915..1119307 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
AM397_RS05515 1119459..1120118 + 660 WP_001221493.1 two-component system response regulator QseB -
AM397_RS05520 1120115..1121464 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
AM397_RS05525 1121510..1121842 - 333 WP_000917685.1 DUF2645 family protein -
AM397_RS05535 1122161..1122742 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
AM397_RS05540 1122773..1123087 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T77231 WP_000415584.1 NZ_CP021736:c1118175-1117879 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T77231 NZ_CP021736:c1118175-1117879 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT77231 WP_000650107.1 NZ_CP021736:c1117877-1117482 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT77231 NZ_CP021736:c1117877-1117482 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References