Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 141565..142337 | Replicon | plasmid p5D_Fsymbiotica-1 |
| Accession | NZ_CP021660 | ||
| Organism | Candidatus Fukatsuia symbiotica strain 5D | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | CCS41_RS14445 | Protein ID | WP_119797893.1 |
| Coordinates | 141565..141876 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | CCS41_RS14450 | Protein ID | WP_119797881.1 |
| Coordinates | 141873..142337 (+) | Length | 155 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CCS41_RS14415 | 137365..137694 | + | 330 | WP_162860122.1 | hypothetical protein | - |
| CCS41_RS14420 | 137938..138960 | - | 1023 | WP_119797794.1 | IS630 family transposase | - |
| CCS41_RS14425 | 139060..139809 | + | 750 | Protein_132 | transposase | - |
| CCS41_RS14430 | 140143..140772 | + | 630 | WP_119797879.1 | AAA family ATPase | - |
| CCS41_RS14435 | 140769..141002 | + | 234 | WP_119797880.1 | hypothetical protein | - |
| CCS41_RS14440 | 141102..141463 | + | 362 | Protein_135 | IS630 family transposase | - |
| CCS41_RS14445 | 141565..141876 | + | 312 | WP_119797893.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| CCS41_RS14450 | 141873..142337 | + | 465 | WP_119797881.1 | helix-turn-helix domain-containing protein | Antitoxin |
| CCS41_RS14455 | 142442..142735 | + | 294 | WP_119797882.1 | DUF1778 domain-containing protein | - |
| CCS41_RS14460 | 142732..143232 | + | 501 | WP_119797883.1 | GNAT family N-acetyltransferase | - |
| CCS41_RS14465 | 143389..143703 | - | 315 | WP_119797884.1 | helix-turn-helix domain-containing protein | - |
| CCS41_RS14475 | 143849..144367 | - | 519 | WP_119797885.1 | type II toxin-antitoxin system YhaV family toxin | - |
| CCS41_RS14480 | 144376..144741 | - | 366 | WP_119797886.1 | type II toxin-antitoxin system PrlF family antitoxin | - |
| CCS41_RS14485 | 144933..145914 | + | 982 | Protein_143 | transposase | - |
| CCS41_RS14490 | 146034..146303 | - | 270 | WP_119797887.1 | hypothetical protein | - |
| CCS41_RS14495 | 146303..146938 | - | 636 | WP_119797888.1 | AAA family ATPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..148316 | 148316 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12179.06 Da Isoelectric Point: 10.3341
>T76915 WP_119797893.1 NZ_CP021660:141565-141876 [Candidatus Fukatsuia symbiotica]
MHVISRQPFNEAAGKFPNCATALADLLRSLEKGKFGSPDEMKKVISSLDNFRYRNKWWVIDVSGNTLRLITYINFRLRKV
FVKHISTHAEYDKLTKYYREHKE
MHVISRQPFNEAAGKFPNCATALADLLRSLEKGKFGSPDEMKKVISSLDNFRYRNKWWVIDVSGNTLRLITYINFRLRKV
FVKHISTHAEYDKLTKYYREHKE
Download Length: 312 bp
>T76915 NZ_CP021660:141565-141876 [Candidatus Fukatsuia symbiotica]
TTGCACGTTATCAGCAGACAACCGTTCAATGAAGCCGCTGGAAAATTTCCGAATTGTGCTACGGCTCTTGCTGATTTATT
GAGATCCCTCGAAAAAGGGAAGTTTGGTAGTCCAGATGAAATGAAGAAGGTGATCTCGTCACTGGATAATTTCCGTTATC
GCAATAAGTGGTGGGTGATTGATGTATCGGGTAATACATTAAGGCTGATCACCTATATTAATTTTCGGTTACGGAAGGTT
TTTGTTAAACACATTTCCACTCATGCTGAATACGATAAACTGACGAAATATTATCGGGAGCACAAAGAATGA
TTGCACGTTATCAGCAGACAACCGTTCAATGAAGCCGCTGGAAAATTTCCGAATTGTGCTACGGCTCTTGCTGATTTATT
GAGATCCCTCGAAAAAGGGAAGTTTGGTAGTCCAGATGAAATGAAGAAGGTGATCTCGTCACTGGATAATTTCCGTTATC
GCAATAAGTGGTGGGTGATTGATGTATCGGGTAATACATTAAGGCTGATCACCTATATTAATTTTCGGTTACGGAAGGTT
TTTGTTAAACACATTTCCACTCATGCTGAATACGATAAACTGACGAAATATTATCGGGAGCACAAAGAATGA
Antitoxin
Download Length: 155 a.a. Molecular weight: 17233.68 Da Isoelectric Point: 4.8631
>AT76915 WP_119797881.1 NZ_CP021660:141873-142337 [Candidatus Fukatsuia symbiotica]
MTIATMFHSERLDAASAAQMVNAFSQVVKSIPLLGGRNNEAEYKKALELIEYLVDRDDLENPLFEPLAAKIAEYENTAPK
FEEFNRLLENVLQGGIAVLRTIMDQYGLKAADLESELGSKSNVSNILNGRRALTVHHIKALSERFHIPAEMFID
MTIATMFHSERLDAASAAQMVNAFSQVVKSIPLLGGRNNEAEYKKALELIEYLVDRDDLENPLFEPLAAKIAEYENTAPK
FEEFNRLLENVLQGGIAVLRTIMDQYGLKAADLESELGSKSNVSNILNGRRALTVHHIKALSERFHIPAEMFID
Download Length: 465 bp
>AT76915 NZ_CP021660:141873-142337 [Candidatus Fukatsuia symbiotica]
ATGACTATAGCAACGATGTTTCATAGTGAGCGCCTTGATGCCGCCAGTGCTGCACAAATGGTTAATGCTTTTTCGCAGGT
GGTAAAATCTATCCCCCTGCTTGGCGGAAGAAATAACGAAGCTGAGTATAAAAAAGCTCTTGAGCTGATAGAGTATCTTG
TAGACCGCGACGATCTGGAGAACCCGCTATTTGAGCCTCTTGCCGCAAAAATCGCCGAATATGAAAACACAGCACCAAAG
TTTGAAGAATTCAATCGCCTGTTAGAAAATGTATTACAGGGTGGTATTGCCGTACTCCGCACCATCATGGATCAGTACGG
TTTGAAAGCCGCAGATCTTGAATCAGAACTGGGATCTAAATCAAATGTGAGCAATATTCTAAATGGCCGCCGTGCTCTAA
CCGTCCATCATATTAAAGCATTGTCTGAACGTTTCCATATTCCCGCTGAAATGTTCATAGATTAA
ATGACTATAGCAACGATGTTTCATAGTGAGCGCCTTGATGCCGCCAGTGCTGCACAAATGGTTAATGCTTTTTCGCAGGT
GGTAAAATCTATCCCCCTGCTTGGCGGAAGAAATAACGAAGCTGAGTATAAAAAAGCTCTTGAGCTGATAGAGTATCTTG
TAGACCGCGACGATCTGGAGAACCCGCTATTTGAGCCTCTTGCCGCAAAAATCGCCGAATATGAAAACACAGCACCAAAG
TTTGAAGAATTCAATCGCCTGTTAGAAAATGTATTACAGGGTGGTATTGCCGTACTCCGCACCATCATGGATCAGTACGG
TTTGAAAGCCGCAGATCTTGAATCAGAACTGGGATCTAAATCAAATGTGAGCAATATTCTAAATGGCCGCCGTGCTCTAA
CCGTCCATCATATTAAAGCATTGTCTGAACGTTTCCATATTCCCGCTGAAATGTTCATAGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|