Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2570845..2571407 Replicon chromosome
Accession NZ_CP021659
Organism Candidatus Fukatsuia symbiotica strain 5D

Toxin (Protein)


Gene name higB Uniprot ID A0A2U8IAY1
Locus tag CCS41_RS12490 Protein ID WP_072550545.1
Coordinates 2570845..2571123 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2U8I7J6
Locus tag CCS41_RS12495 Protein ID WP_072550534.1
Coordinates 2571123..2571407 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCS41_RS12475 2566543..2567874 + 1332 WP_119797616.1 two-component system sensor histidine kinase EnvZ -
CCS41_RS12480 2567917..2568297 - 381 WP_072550532.1 VOC family protein -
CCS41_RS12485 2568628..2569683 - 1056 WP_072550533.1 hypothetical protein -
CCS41_RS15740 2570196..2570384 + 189 WP_083429615.1 hypothetical protein -
CCS41_RS12490 2570845..2571123 + 279 WP_072550545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCS41_RS12495 2571123..2571407 + 285 WP_072550534.1 HigA family addiction module antidote protein Antitoxin
CCS41_RS12505 2571816..2572067 - 252 WP_072550536.1 pyocin activator PrtN family protein -
CCS41_RS12520 2573742..2574464 - 723 WP_072550538.1 helix-turn-helix transcriptional regulator -
CCS41_RS12525 2574699..2574968 - 270 WP_072550539.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2490566..2677982 187416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10535.03 Da        Isoelectric Point: 6.7081

>T76911 WP_072550545.1 NZ_CP021659:2570845-2571123 [Candidatus Fukatsuia symbiotica]
MIKSFEHKGLKKFFLKDDSSGIEQKLVNRIKTRLTVIDAASCTDGIDMPGYDLHQLNGDRKDIWSISVSGNWCITFRFID
GDAKILNLEDYH

Download         Length: 279 bp

>T76911 NZ_CP021659:2570845-2571123 [Candidatus Fukatsuia symbiotica]
ATGATAAAAAGCTTTGAGCATAAGGGGTTGAAAAAGTTTTTCCTCAAAGACGATAGTAGTGGCATTGAGCAGAAATTGGT
TAACCGTATAAAAACACGGCTTACCGTAATTGACGCCGCTAGCTGCACAGACGGAATCGACATGCCTGGCTACGATCTGC
ATCAGCTTAACGGTGATCGTAAAGACATCTGGTCAATTAGTGTTTCCGGTAACTGGTGTATTACTTTCAGATTTATTGAT
GGTGATGCAAAAATTCTCAACTTGGAGGATTATCACTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10393.96 Da        Isoelectric Point: 7.4020

>AT76911 WP_072550534.1 NZ_CP021659:2571123-2571407 [Candidatus Fukatsuia symbiotica]
MRMANPAYPGEIIAETLEDMHVSLRQFAKAMDIAPSTASRLLSGQTTVTPEMALRLSAVVGSTPETWLKIQTNYSLHEAR
QKTDISHLHKLAFA

Download         Length: 285 bp

>AT76911 NZ_CP021659:2571123-2571407 [Candidatus Fukatsuia symbiotica]
ATGAGAATGGCTAACCCTGCCTACCCTGGCGAAATTATTGCAGAAACGCTGGAAGACATGCATGTGAGTCTCCGACAGTT
CGCAAAAGCAATGGATATAGCACCGTCAACGGCCAGTCGGTTACTATCTGGTCAAACCACAGTCACGCCGGAAATGGCAT
TGAGACTGTCAGCCGTTGTTGGCAGCACCCCTGAAACCTGGTTAAAAATACAGACAAATTACAGTTTGCATGAAGCCAGA
CAAAAAACAGACATCAGCCATTTGCACAAACTGGCTTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U8IAY1

Antitoxin

Source ID Structure
AlphaFold DB A0A2U8I7J6

References