Detailed information of TA system TA076907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1205026..1205527
• Replicon: chromosome
• Accession: NZ_CP021659
• Organism: Candidatus Fukatsuia symbiotica strain 5D

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CCS41_RS05920
• Protein ID: WP_119797338.1
• Coordinates: 1205026..1205280 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CCS41_RS05925
• Protein ID: WP_119797339.1
• Coordinates: 1205273..1205527 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCS41_RS05880	1200079..1200597	-	519	WP_119797333.1	lysozyme	-
CCS41_RS05885	1200594..1200780	-	187	Protein_1151	class II holin family protein	-
CCS41_RS05890	1201176..1201487	+	312	WP_205411496.1	hypothetical protein	-
CCS41_RS05910	1202581..1203863	-	1283	Protein_1153	cytosine permease	-
CCS41_RS05915	1203969..1204691	-	723	WP_119797732.1	LuxR family transcriptional regulator	-
CCS41_RS05920	1205026..1205280	-	255	WP_119797338.1	Txe/YoeB family addiction module toxin	Toxin
CCS41_RS05925	1205273..1205527	-	255	WP_119797339.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CCS41_RS05930	1205641..1205958	-	318	WP_205411497.1	hypothetical protein	-
CCS41_RS16050	1206118..1206249	-	132	Protein_1158	Bro-N domain-containing protein	-
CCS41_RS05935	1206197..1206430	-	234	WP_205411498.1	hypothetical protein	-
CCS41_RS05940	1206823..1207311	-	489	WP_119797733.1	DUF1133 family protein	-
CCS41_RS05945	1207404..1207997	-	594	WP_119797340.1	phosphohydrolase	-
CCS41_RS05950	1207997..1208959	-	963	WP_119797341.1	replication protein	-
CCS41_RS05955	1209072..1209518	-	447	WP_119797342.1	hypothetical protein	-
CCS41_RS05960	1209584..1209814	-	231	WP_119797343.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1196892..1274742	77850

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-55)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10374.92 Da
• Isoelectric Point: 10.0202

>T76907 WP_119797338.1 NZ_CP021659:c1205280-1205026 [Candidatus Fukatsuia symbiotica]
MNKLFTDESWRDYLYWQQNDKKLVKRINELIKDIERTPFSGIGKPKSLKHNLSGYWSRRINEEHRLIYKIDDTRIVIISC
RYHY

Nucleotide

• Length: 255 bp

>T76907 NZ_CP021659:c1205280-1205026 [Candidatus Fukatsuia symbiotica]
ATGAATAAGCTTTTTACTGACGAATCCTGGCGAGATTACCTTTACTGGCAACAAAACGATAAAAAGCTTGTTAAGAGGAT
TAATGAGCTTATTAAAGATATAGAGCGTACTCCTTTTAGTGGCATAGGTAAGCCTAAGTCTTTAAAACATAATTTATCTG
GTTATTGGTCACGACGAATTAACGAAGAACACCGGCTTATATATAAAATAGACGATACACGTATAGTGATTATATCGTGT
CGTTATCATTACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9324.56 Da
• Isoelectric Point: 4.5337

>AT76907 WP_119797339.1 NZ_CP021659:c1205527-1205273 [Candidatus Fukatsuia symbiotica]
MFNTTYSAARKNLASIMTQTVQDCEPILITRKNGEDCVLISSSEYGSLKETADLLLCSPANTMHLLTSLEQASKGELRER
QLDE

Nucleotide

• Length: 255 bp

>AT76907 NZ_CP021659:c1205527-1205273 [Candidatus Fukatsuia symbiotica]
ATGTTTAACACAACTTATAGCGCCGCCAGGAAAAATCTTGCTTCAATCATGACTCAAACCGTTCAGGATTGTGAACCCAT
ACTGATAACACGGAAAAATGGAGAAGATTGTGTTTTGATTTCCAGTTCAGAGTACGGAAGTCTTAAAGAAACCGCTGATC
TACTACTATGCTCTCCAGCAAATACCATGCACCTGCTAACATCGTTAGAGCAGGCGAGTAAAGGGGAATTGCGGGAACGT
CAGCTTGATGAATAA